1. The chiral proton pump inhibitor omeprazole is converted in the parietal cells of the stomach into an achiral sulphenamide intermediate. The sulphenamide is electrophilic and reacts with a thiol (–SH) function on the proton pump (a H+/K+ ATPase) to form a disulfide bond, thereby inhibiting the pump and slowing the secretion of protons into the stomach.
Source: Stereochemistry, The Organic Chemistry of Medicinal Agents
Citation: Renslo A. The Organic Chemistry of Medicinal Agents; 2016 Available at: Accessed: December 31, 2017
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