1. Effects of Intravenous General Anesthetics on [(3) H]GABA Release from Rat Cortical Synaptosomes 
Anesthes. 1998;89(4):
Figure Legend:
Figure 1. Propofol enhancement of spontaneous and potassium chloride-evoked [(3) H][Greek small letter gamma]-aminobutyric acid (GABA) release. Synaptosomes were superfused with HEPES-buffered medium (HBM) or 15 mM potassium chloride +/− propofol (5-100 [micro sign]M, nominal concentration) during 6-10 min of superfusion. Curves show peak [(3) H] GABA release (mean +/− SEM) in propofol-treated synaptosomes as a percentage of HBM or potassium chloride control. Propofol values plotted were measured by high-pressure liquid chromatography. The median effective values of propofol to enhance spontaneous and potassium chloride-evoked [(3) H]GABA release were 7.1 +/− 3.4 [micro sign]M and 5.4 +/− 2.8 [micro sign]M, respectively. **P < 0.01 versus HBM or potassium chloride value (n = 6).
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