1. Volume 17, Issue 2, Pages 327-333 (February 2009)
Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates 
Nicola Brunetti-Pierri, Gary E Stapleton, Mark Law, John Breinholt, Donna J Palmer, Yu Zuo, Nathan C Grove, Milton J Finegold, Karen Rice, Arthur L Beaudet, Charles E Mullins, Philip Ng 
Molecular Therapy 
Volume 17, Issue 2, Pages (February 2009)
DOI: /mt
Copyright © 2009 The American Society of Gene Therapy Terms and Conditions

2. Figure 1
A sausage-shaped balloon catheter is positioned in the inferior vena cava (IVC) under fluoroscopic guidance. Inflation of the balloon with contrast medium results in hepatic venous outflow occlusion from the hepatic veins (HVs). The HDAd is administered by injection through a percutaneously positioned hepatic artery (HA) catheter. Fluoroscopic image of balloon inflation with contrast medium from baboon is shown on the left. Fluoroscopic image of injection of contrast medium into the HA from baboon is shown on the right.
Molecular Therapy  , DOI: ( /mt )
Copyright © 2009 The American Society of Gene Therapy Terms and Conditions

3. Figure 2
Transgene levels and toxicity measurements for baboons injected with 1 × 1011 viral particles (vp)/kg. (a) Serum baboon α-fetoprotein (bAFP) levels, (b) alanine aminotransferase (ALT), (c) aspartate aminotransferase (AST), and (d) interleukin-6 (IL-6) levels in baboons injected 1 × 1011 vp/kg of HDΔ21.7E4PEPCK-bAFP-WL or saline. Numbers in parenthesis represent the normal range, if known.
Molecular Therapy  , DOI: ( /mt )
Copyright © 2009 The American Society of Gene Therapy Terms and Conditions

4. Figure 3
Transgene levels and toxicity measurements for baboons injected with 3 × 1010 and 1 × 1010 viral particles (vp)/kg. (a) Serum baboon α-fetoprotein (bAFP) levels, (b) alanine aminotransferase (ALT), (c) aspartate aminotransferase (AST), and (d) interleukin-6 (IL-6) levels in baboons injected 3 × 1010 or 1 × 1010 vp/kg of HDΔ21.7E4PEPCK-bAFP-WL. Numbers in parenthesis represent the normal range, if known.
Molecular Therapy  , DOI: ( /mt )
Copyright © 2009 The American Society of Gene Therapy Terms and Conditions

5. Figure 4
Histopathology of baboon livers. Hematoxylin and eosin histology of liver from baboon at (a) day 8 and (b) day 28, baboon at (c) day 7 and (d) day 28, (e) baboon at day 28 and (f) baboon at day 28 showing rare and minor abnormalities.
Molecular Therapy  , DOI: ( /mt )
Copyright © 2009 The American Society of Gene Therapy Terms and Conditions