1. Dr. AKM Shafiqul Islam School of Bioprocess Industry 10.10.08
Application of Organic Chemistry in Process Industry: Synthesis of Paracetamol, Aspirin and Saccharin
Dr. AKM Shafiqul Islam
School of Bioprocess Industry

2. Anitpyratic and Analgesic
Paracetamol
acetaminophen
Acetyl salicylic acid

3. Aspirin
Willow Bark

4. Methyl 2-hydroxynenzoate
Aspirin Synthesis
Methyl 2-hydroxynenzoate
(Oil of wintergreen)
Sodium 2-hydroxybenzoate

5. Aspirin Synthesis
Sodium 2-hydroxybenzoate
Salicylic acid

6. Aspirin Synthesis
Acetyl salicylic acid

7. Paracetamol Synthesis
4-nitrophenol
MP= oC
BP=278oC
2-nitrophenol
MP=44-45oC
BP=213oC

8. Paracetamol Synthesis

9. Paracetamol Synthesis
acetaminophen

10. Saccharin Synthesis form Benzene
Fridel-Craft reaction
Salfonation reaction

11. Oxidation
Excess SOCl2

12. Reaction with Ammonia
Saccharin