1. aspartate / aspartic acid
Bellwork: Using the codon charts in your notes, fill in the boxes below. **Remember to use mRNA when doing translation**
AUG
CCG
CAU
CCC
GGU
UCG
CGA
CUA
alanine
glycine
serine
aspartate / aspartic acid

2. Science Fact of the Day: The world’s termites outweigh the world’s humans 10 to 1.

4. CO: I will identify and evaluate the effects of mutations in DNA
CO: I will identify and evaluate the effects of mutations in DNA. LO: I will write notes. I will read a paragraph and fill in the missing words. I will model DNA mutations.

5. Think about it: What happens if our DNA gets messed up?

6. Cells sometimes make mistakes when copying their own DNA
Cells sometimes make mistakes when copying their own DNA. These mistakes are called mutations. Mutations are changes in the genetic material.
NOTE: mutations can also be caused by environmental factors like radiation

7. Types of Mutations

8. Point Mutations: gene mutations involving changes in one or a few nucleotides - Three types of point mutations are substitutions, insertions, and deletions.

9. Frameshift Mutation: a nucleotide is added or deleted
Frameshift Mutation: a nucleotide is added or deleted - the bases are still read in groups of three - those groupings are shifted for every codon that follows.

10. Sequences with Blocks

11. Think-pair-share
Would a frame shift mutation or a point mutation cause a bigger effect in an organism? Why?

12. mutation
point
frameshift
protein

14. Do you know of any diseases caused by genetic mutations?

15. Sickle Cell Anemia
These are the sickle-shaped blood cells of someone with sickle cell anemia. Sickle cell anemia is the result of a point mutation, a change in just one nucleotide in the gene for hemoglobin. This mutation causes the hemoglobin in red blood cells to distort to a sickle shape when deoxygenated. The sickle-shaped blood cells clog in the capillaries, cutting off circulation. Having two copies of the mutated genes cause sickle cell anemia, but having just one copy does not, and can actually protect against malaria - an example of how mutations are sometimes beneficial.

16. Color Blindness
Most forms are caused by a point mutation on the X chromosome.
What number do you see? A color blind person won’t see anything. A color deficient person may see the number 35

17. Achondroplasia
This is the most common form of dwarfism. It is caused by a substitution mutation for the gene that codes for bone growth.