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Transient Receptor Potential (TRP) Channels

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Presentation on theme: "Transient Receptor Potential (TRP) Channels"— Presentation transcript:

1 Transient Receptor Potential (TRP) Channels
First discovered in Drosophila: Drosophila eye에서 photo-transduction Light → rhodopsin → GPCR → G transducin → PLC activation → Ca2+ → currents → channel activation

2 Transient receptor potential channel in Drosophila Eye
Craig Montel & Gerald M Rubin. Molecular Characterization of the Drosophila trp locus: A Putative Integral Membrane Protein Required for Phototransduction. Neuron, 1989

3 Discovery of VR1 (capsaicin receptor) in mouse DRG neurons
Michael J. Caterina et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997

4 TRPV1 is activated by heat!
Tominaga, Neuron 1998

5 Classification of TRP channels
Nonselective Cation channels

6 TRP channels are activated by natural ingredients

7 TRP Channels: Molecular Sensors
Capsaicin 감각 신경 척수 유해자극 (열, 압력, 캡사이신) 대뇌 통증 전달 경로 이온채널 heat

8

9 TRPV4-associated skeletal dysplasias

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