1. Principal designs of NTF application to the Parkinsonian brain
Principal designs of NTF application to the Parkinsonian brain. (A) Rodent experiments where the neurotoxin 6-OHDA is injected into the striatum, substantia nigra (SN) or medial forebrain bundle (MFB). The NTFs could be injected to the striatum or SN either before (neuroprotection) or after (neurorestoration) the toxins. (B) For patient treatments, the NTFs can be delivered to the caudate putamen either as the recombinant proteins using the peristaltic pumps, genes encoding NTFs using the adeno accociated viral vectors (AAV), or the engineered cells using encapsulated cell biodelivery (ECB). Application to the SN could also be considered.
Source: Chapter 7. Neurotrophic Factors, Movement Disorders, 3e
Citation: Watts RL, Standaert DG, Obeso JA. Movement Disorders, 3e; 2012 Available at: Accessed: January 02, 2018
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