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Pharmacokinetics. Pharmacokinetics Oral administration Blood concentration after oral administration Cmax Concentration Concentration tmax Time Time.

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Presentation on theme: "Pharmacokinetics. Pharmacokinetics Oral administration Blood concentration after oral administration Cmax Concentration Concentration tmax Time Time."— Presentation transcript:

1

2 Pharmacokinetics

3 Oral administration Blood concentration after oral administration
Cmax Concentration Concentration tmax Time Time Blood concentration after oral administration Blood concentration after repeated oral administration

4 IV administration Blood concentration during a repeated intravenously
Accumulation phase Equilibrium phase Decrease phase Concentration Concentration Time Time Blood concentration during a repeated intravenously administration Blood concentration during a perfusion

5 Exponential decrease of plasmatic concentraion
Concentration Concentration Time Time Exponential decrease of plasmatic concentraion Pluriexponential decrease of plasmatic concentration

6 Normal people People suffering from renal insufficiency
Emax Concentration Effect intensity Time Normal people Concentration Plasmatic concentration Therapeutic effect Time Side effects People suffering from renal insufficiency Dose/effect link

7 Blood concentration with and without enterohepatic recycling
With enterohepatic recycling Without enterohepatic recycling Concentration Time Blood concentration with and without enterohepatic recycling

8 Gauss curve


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