1. DISORDERS DUE TO DEFECTS IN COLLAGEN

3. Defects in Type I collagen cause:
OSTEOGENESIS IMPERFECTA
Blue sclera
In support of chapter 8, pg. 6
Left panel from Langlais - Color Atlas of Common Oral Diseases. See the DVD.
Right panel from Wikipedia.

4. Defects in Type I collagen cause:
DENTINOGENESIS IMPERFECTA
Abraded teeth in Dentinogenesis Imperfecta
Opalescent and cracked teeth
In support of chapter 8, pg. 6
Left panel from Langlais - Color Atlas of Common Oral Diseases. See the DVD.
Right panel from Wikipedia.
Type I: associated with OI.
Will probably need full crown coverage.

6. An example of a mutation underlying Osteogenesis Imperfecta
988
Pro Gly Pro Arg Gly Arg Thr Gly Asp Ala
CCG GGT CCT CGC GGT CGC ACT GGT GAT GCT
Pro Cys Pro Arg Gly Arg Thr Gly Asp Ala
CCT TGT CCT CGC GGT CGC ACT GGT GAT GCT
In support of Chapter 8, pg. 6.

7. Ehlers-Danlos Syndrome
Hyperplasticity of the skin
In support of chapter 8, pg. 6
From Mosby's Medical, Nursing and Allied Health Dictionary. See DVD.

8. Perifollicular abnormalities. Gingival abnormalities
Scurvy
In support of chapter 8, pg. 8.
Figs. from Hisrschmann, J.V., and Raugi, G. J. Adult scurvy. J. Am. Acad. Dermatol. 41: (1999)
Perifollicular abnormalities.
Gingival abnormalities

9. Genetic defects in elastin underlie Williams Syndrome
Facial features associated with Williams Syndrome
Dental features include small widely spaced teeth and malocclusion.
In support of chapter 8, pg. 10.
From Morris CA, and Mervis CB. Williams Syndrome and related disorders. Ann. Rev. Genomics Hum. Genet. 1: (2000).

10. Abraham Lincoln is thought to have had Marfan’s syndrome.
Image from Wikipedia.

11. Aortic Aneurysm
CT reconstruction of an aortic aneurysm. The Figure is from Wikipedia.