1. Schematic working model of the hepatic microsomal glucose-6-phosphatase system. ER = endoplasmic reticulum. This model is not meant to represent the actual topology of the proteins in the membrane. The stoichiometry of each of the proteins is unknown, and it is unknown whether these proteins form a complex in the membrane. Phosphate transporter and glucose transporter proteins have not been unequivocally demonstrated and an alternative model that characterizes glucose 6-phosphatase as an integral channel-protein of the microsomal membrane, having both catalytic and transport functions, has been proposed.447 In the alternative model, all transporter proteins would be missing from the diagram.
Source: Glycogen Storage Diseases, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: January 03, 2018
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