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GRAPHS AND STUFF YOU NEED TO BE ABLE TO DRAW

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Presentation on theme: "GRAPHS AND STUFF YOU NEED TO BE ABLE TO DRAW"— Presentation transcript:

1 GRAPHS AND STUFF YOU NEED TO BE ABLE TO DRAW
Christchurch Anaesthesia Primary Revision Course

2 AIMS What you need to draw How to draw it
NOT detailed physiology or pharmacology!

3 RESPIRATORY Oxyhaemoglobin dissociation curve (also content)
Effect of C02, temperature, 2,3-DPG Myoglobin Fetal Hb Anaemia Pregnancy / Double Bohr effect CO2 dissociation curve Oxygen cascade Ventilatory response to CO2 and O2 Spirometry flung volumes (also changes in pregnancy) Closing capacity and FRC vs. age Single breath nitrogen washout Dynamic compliance curve (pressure-volume curve) showing work of breathing Static pressure-volume curve and compliance Flow volume loop Distribution of ventilation and blood flow in upright lung Pressures, volumes, flows during a breathing cycle PVR versus lung volume Know about: Iso shunt diagram VQ line (oxygen vs. carbon dioxide curve)

4 CARDIOVASCULAR Wigger's diagram (will be asked to draw parts of it)
ECG LA, LV, aortic pressures LV volume CVP Aortic root pressure Heart sounds CVP or RA pressure waveform PA catheter pressure changes Aortic and radial pressure waveforms ECG (also vectors) LV pressure-volume loop Starling curve and variations Coronary artery blood flow (cf aortic root pressure trace) Cardiac output and venous return curves (may be asked by some examiners) Normal Haemorrhage Vasoconstriction Vasodilation Changes during the Valsalva manoeuvre Depolarisation of SAN, AVN, ventricular muscle (including phases, ion fluxes)

5 RENAL MEASUREMENT NEUROPHYSIOLOGY
CBF autoregulation curve (CBF vs. MABP) - change with anaesthesia CBF versus pCO2, pO2 Intracranial elastance curve (ICP vs. intracranial volume) Nerve action potential Renal autoregulation curve (RBF and GFR vs. MABP) Glucose tmax MEASUREMENT Absorption curves for Hb and HbO2 Capnograph

6 PHARMACOKINETICS PHARMACODYNAMICS
Dose-response curves (graded and quantal) Agonist I antagonist I partial antagonist etc. Therapeutic index Drug effects Effect of volatiles or opioids on CO2 ventilatory response curve Effect of volatiles on CBF autoregulation Drug ionisation vs. pH Alfentanil / fentanyl STP, lignocaine Exponential function curve -half-life, time constant etc. Curves for volatile agents (with values) Wash-in Wash-out Concentration vs. time curves First order -concentration vs. time after iv bolus dose Effect site concentration vs. time Propofol bolus - plasma and effect site concentrations Zero order Context sensitive half-times for opioids

7 DRUG STRUCTURES (usually identify rather than draw)
Barbiturate structure (keto and enol forms of STP) Propofol Volatile agents (halothane, isoflurane, sevoflurane, desflurane) Sympathomimetics (synthesis and structure-activity relationships) Examples of isomers Identify +/-discuss structure-activity Opioids (morphine, fentanyl) Local anaesthetics Neuromuscular blockers

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21 Power & Kam

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33 Kenny & Davis

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37 Berne & Levy

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