1. 2-Lysine Derived Alkaloids
Piperidine Alkaloids

2. Lysine Derived Alkaloids
As the next homologue to ornithine, lysine and its associated compounds give rise to a number of alkaloids, some of which are analogous to the ornithine group.

4. LOBELIA
Lobelia BHP; BP 1988 (Lobelia Herb, Indian Tobacco) consists of the dried aerial parts of Lobelia inflata (Campanulaceae), an annual herb indigenous to the eastern USA and Canada. It is cultivated in the USA and Holland.

7. Lobelia inflata Campanulaceae
Constituents: Lobelia contains about % of alkaloids (BP 1988, not less than 0.25% as determined by a standard stas-Otto procedure) the most important of which is lobeline.
Uses:
Minor alkaloids identified include closely related structures, e.g. lobelanine . The North American Indians employed lobelia as an alternative or substitute for tobacco (Nicotiana tabacum; Solanaceae), and it is found that lobeline stimulates nicotinic receptor sites in a similar way to nicotine, but with a weaker effect.
Lobeline has been employed in preparations
intended as smoking deterrents. The crude plant drug has also long been used to relieve asthma and bronchitis, though in large doses it can be quite toxic.

8. Biosynthesis of lobeline

9. Pomegranata
The barks, fruit-rind and seeds of the pomegranate, Punica granatum (Punicaceae) all find medicinal use.
Both stem and root barks are used and occur in curved or channeled pieces about 5-10cm long and 1-3cm wide.
Constituents: They contain about % of volatile liquid alkaloids, the chief of which are pelletierine and pseudopelletierine, together with about 22% of tannin.
Uses: anthelminthic, Tapeworms, Astringent.
Seed extract for use in the treatment of diarrhea, (Antidiarrhoea).

11. Punica granatum
Punicaceae

14. Chemical composition
PELLETIERINE

15. Piper nigrum The pungency of the fruits of black pepper
(Piper nigrum; Piperaceae), a widely used
condiment, is mainly due to the piperidine alkaloid
Piperine. In this structure, the piperidine ring forms part of a tertiary amide structure, and is incorporated via piperidine itself, the reduction product of Δ1-piperideine

18. Nicotine, Nicotinic acid & Arecoline
3-Nicotinic Acid Derived Alkaloids
Pyridine Alkaloids
Nicotine, Nicotinic acid & Arecoline
Pyridine Nicotine
Tryptophan
Nicotinic Acid

19. PYRIDINE PIPERIDINE ALKALOIDE :

20. Nicotina Tabacum L.N: Nicotina tabacum F.N: Solanaceae
Part used: leaves
Use: vermicide

22. Constituents :
I. nicotine II. Anabasine III. Chlorogenic Ac IV. Cafeic Ac V. Nicotinic Ac

23. N
COOH
Nicotinic Ac
CH=CH─COOH HO
Cafeic Ac OH H
CH=CH─ C O HO
COOH
chlorogenic Ac

24. Biosynthesis of nicotine :

25. أكثر من 1000 مادة سامة تنتج عن احتراق التبغ و 40 منها على الأقل تؤهب لحدوث السرطان

34. Areka L.N : Areca catechu F.N : palmeae
Part Used : fruit extract or juice

37. Chemical composition:
Contains several alkaloids which are reduced pyridine derivatives .
CH3
COOCH3
Areclline hydrobromid H N+
Br¯
Use & Dose
in veterinary medicine (anti helmentic)

38. Conium Maculatum L.N: conium maculatum F.N: umbelliferae (apiaceae)
Part used: fruit

40. Chemical composition :
coniine , the major alkaloid and conine conceine .
Use & Dose
antispasmodic / sedative / water hemlock / species / very toxic drug