1. NATURAL PRODUCT CHEMISTRY
TRI JOKO RAHARJO

2. Scopes Introduction Primary metabolism Biosynthesis pyruvate
Biosynthesis shikimate
Lignin and lignan
Extension of phenil propanoate
Polyketide and Flavonoid
Terpenoid
Alkaloid
Isolation and Identification

3. Introduction Primary and Secondary Metabolites
Primary Met: Essential molecules for survive of living things (protein, carbohydrate, DNA, lipid)
Secondary Met. : Molecules which are species specific with certain function
Asetyl-CoA (polyketide precursor)
Shikimic acid (aromatic precursor)
Mevalonic acid (terpenoid precursor)
Amino acid (precursor for peptide, alkaloid, pinicillin)

4. Introduction Secondary Met. Characteristic and function
Species /genus/family specific
Certain function: respond to environment condition

5. Introduction
ASETYL-COA, Key intermediete

6. Primer Metabolism Process

7. Primer Metabolism Process
Primer metabolism related to plants: fotosynthesis

8. ASETYL-COA, Key intermediete
Carbohydrate, protein lipid, DNA
catabolism
Asetyl-CoA
anabolism
Carbohydrate, protein lipid, DNA, Secondary Met.

9. ASETYL-COA, Key intermediete
MALONYL-COA, key partners for ASETIL-COA

10. ASETYL-COA, Key intermediete
HOW IS ASETIL-COA USED IN BIOSYNTHESIS
Fatty acid synthase (FAS)
Polyketide synthase (PKS)