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Cancer-specific mortality
Role of Lymph Node Dissection during Radical Nephroureterectomy for Upper Urinary Tract Urothelial Cancer: Multi-institutional Large Retrospective Study JCOG1110A, World Journal of Urology Junichi Inokuchi1, Kentaro Kuroiwa2, Yoshiyuki Kakehi3, Mikio Sugimoto3, Toshiki Tanigawa4, Hiroyuki Fujimoto5, Momokazu Gotoh6, Naoya Masumori7, Osamu Ogawa8, Masatoshi Eto1, Chikara Ohyama9, Akito Yamaguchi10, Hideyasu Matsuyama11, Tomohiko Ichikawa12, Tomohiko Asano13, Junki Mizusawa14, Junko Eba14, Seiji Naito 1, 10, * 1 Department of Urology, Graduate School of Medical Sciences, Kyushu University; 2 Department of Urology, Miyazaki Prefectural Miyazaki Hospital; 3 Department of Urology, Faculty of Medicine, Kagawa University; 4 Department of Urology, Niigata Cancer Center Hospital; 5 Urology Division, National Cancer Center Hospital; 6 Department of Urology, Nagoya University Graduate School of Medicine; 7 Department of Urology, Sapporo Medical University School of Medicine; 8 Department of Urology, Kyoto University 9 Department of Urology, Hirosaki University Graduate School of Medicine; 10 Department of Urology, Harasanshin Hospital; 11 Department of Urology, Graduate School of Medicine, Yamaguchi University; 12 Department of Urology, Graduate School of Medicine, Chiba University; 13 Department of Urology, National Defense Medical College; 14 JCOG Data Center/Operations Office, National Cancer Center *Corresponding author. Seiji Naito, Department of Urology, Harasanshin Hospital, address: Supplementary Table S3 Multivariate analysis addressing overall survival and cancer-specific mortality among preoperative and histopathological covariates in the cohort B Variables Parameter Reference Overall survival Cancer-specific mortality HR 95% CI p value Age ≥70 <70 1.66 <0.001 1.06 0.703 Gender female male 0.97 0.794 1.27 0.102 Voided urine cytology positive negative/ false positive 1.20 0.118 1.02 0.866 Preoperative hydronephrosis present absent 0.671 0.98 0.930 Tumour laterality right left 1.08 0.482 1.11 0.445 Neoadjuvant chemotherapy adminstered none 1.23 0.478 1.48 0.263 Type of surgery laparoscopic open 0.71 0.009 0.78 0.097 Primary tumour location ureter renal pelvis 1.13 0.402 1.16 0.418 Pathoplogical T (pT) stage ≥pT3 ≤pT2 2.06 2.45 Concomitant carcinoma in situ 0.99 0.933 0.83 0.346 Tumour grade G3 G1, G2 0.005 1.67 0.004 Lymph vascular invasion (LVI) 2.26 2.99 Surgical margin negative 1.65 0.025 0.057 Lymph node dissection (LND) with LND without LND 0.317 1.42 0.017 HR = hazard ratio; CI = confidence interval
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