1. Cancer-specific mortality
Role of Lymph Node Dissection during Radical Nephroureterectomy for Upper Urinary Tract Urothelial Cancer: Multi-institutional Large Retrospective Study JCOG1110A, World Journal of Urology
Junichi Inokuchi1, Kentaro Kuroiwa2, Yoshiyuki Kakehi3, Mikio Sugimoto3, Toshiki Tanigawa4, Hiroyuki Fujimoto5, Momokazu Gotoh6, Naoya Masumori7, Osamu Ogawa8, Masatoshi Eto1, Chikara Ohyama9, Akito Yamaguchi10, Hideyasu Matsuyama11, Tomohiko Ichikawa12, Tomohiko Asano13, Junki Mizusawa14, Junko Eba14, Seiji Naito 1, 10, *
1 Department of Urology, Graduate School of Medical Sciences, Kyushu University; 2 Department of Urology, Miyazaki Prefectural Miyazaki Hospital; 3 Department of Urology, Faculty of Medicine, Kagawa University; 4 Department of Urology, Niigata Cancer Center Hospital; 5 Urology Division, National Cancer Center Hospital; 6 Department of Urology, Nagoya University Graduate School of Medicine; 7 Department of Urology, Sapporo Medical University School of Medicine; 8 Department of Urology, Kyoto University
9 Department of Urology, Hirosaki University Graduate School of Medicine; 10 Department of Urology, Harasanshin Hospital; 11 Department of Urology, Graduate School of Medicine, Yamaguchi University; 12 Department of Urology, Graduate School of Medicine, Chiba University; 13 Department of Urology, National Defense Medical College; 14 JCOG Data Center/Operations Office, National Cancer Center
*Corresponding author. Seiji Naito, Department of Urology, Harasanshin Hospital, address:
Supplementary Table S3 Multivariate analysis addressing overall survival and cancer-specific mortality among preoperative and histopathological covariates in the cohort B
Variables
Parameter
Reference
Overall survival
Cancer-specific mortality HR
95% CI
p value
Age
≥70
<70
1.66
<0.001
1.06
0.703
Gender
female
male
0.97
0.794
1.27
0.102
Voided urine cytology
positive
negative/ false positive
1.20
0.118
1.02
0.866
Preoperative hydronephrosis
present
absent
0.671
0.98
0.930
Tumour laterality
right
left
1.08
0.482
1.11
0.445
Neoadjuvant chemotherapy
adminstered
none
1.23
0.478
1.48
0.263
Type of surgery
laparoscopic
open
0.71
0.009
0.78
0.097
Primary tumour location
ureter
renal pelvis
1.13
0.402
1.16
0.418
Pathoplogical T (pT) stage
≥pT3
≤pT2
2.06
2.45
Concomitant carcinoma in situ
0.99
0.933
0.83
0.346
Tumour grade G3
G1, G2
0.005
1.67
0.004
Lymph vascular invasion (LVI)
2.26
2.99
Surgical margin
negative
1.65
0.025
0.057
Lymph node dissection (LND)
with LND
without LND
0.317
1.42
0.017
HR = hazard ratio; CI = confidence interval