1. Diagnosis of Solitary Plasmocytoma
history and physical examination
complete blood count, differential, platelet count
serum chemistry for creatinine, albumin, corrected calcium, serum LDH and beta-2 microglobulin
serum quantitative immunoglobulins and protein electrophoresis, 24-h urine for total protein, Bence Jones protein and urine protein electrophoresis, FLC ratio
bone marrow aspiration and biopsy
MFC (for SBP)
MRI or FDG PET
I level
II level
III level
Figure 1: Diagnostic algorithm for SP divided in 3 different steps.

2. Figure 2: Therapeutic algorithm for SP (SBP and SEP).
Treatment of Solitary Plasmocytoma
Solitary Bone Plasmocytoma
Solitary Extramedullary Plasmocytoma
Surgery in case of anatomical instability or neurological compression
Consider surgery in case of upper aerodigestive cases (controversy for head&neck)
Radiotherapy (40 Gy)
Radiotherapy (40 Gy)
Chemotherapy for bulky disease, resistant to radiotherapy, OMD+
Conventional agents, autologous transplantation for young and fit patients, consider novel agents
Figure 2: Therapeutic algorithm for SP (SBP and SEP).