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Detection of XIST RNA in interphase cells from a normal male, a normal female, and a 49,XXXXX female by RNA fluorescence in situ hybridization. Male.

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Presentation on theme: "Detection of XIST RNA in interphase cells from a normal male, a normal female, and a 49,XXXXX female by RNA fluorescence in situ hybridization. Male."— Presentation transcript:

1 Detection of XIST RNA in interphase cells from a normal male, a normal female, and a 49,XXXXX female by RNA fluorescence in situ hybridization. Male cells do not express XIST RNA. Female cells express XIST from the inactive X chromosome, and XIST transcripts remain associated with the Barr body complex. Cells from the 49,XXXXX female have four inactive X chromosomes; each expresses XIST and forms a distinct XIST RNA/Barr body complex. Source: The Sex Chromosomes and X Chromosome Inactivation, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: January 14, 2018 Copyright © 2018 McGraw-Hill Education. All rights reserved

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