1. From: Intraocular Hemorrhage Causes Retinal Vascular Dysfunction via Plasma Kallikrein
Invest. Ophthalmol. Vis. Sci ;54(2): doi: /iovs
Figure Legend:
Effect of autologous blood on retinal leukostasis. (A) Representative images of adherent leukocytes in retinal vessels of a vehicle-treated rat, a BPCCB treated rat subjected to PBS or 10 μL autologous blood intravitreal injection. The majority of the adherent leucocytes were observed in the veins of the Veh-blood group. Scale bar is 64 μm. (B) The number of adherent leukocytes was 4-fold greater in eyes injected with blood than PBS alone in vehicle group (n = 8). BPCCB treatment reduced the number of blood-induced adherent leukocytes (n = 7) and had no effect on PBS injection. **P < 0.01; ***P < 0.001; ns, no significance. (C) Representative retinal images obtained by SLO from eye following intravitreal injection of either BSS or PPK/FXII/HK. Fluorescent acridine orange bound static leukocytes are observed in a greater number within the vascular retina of contact system treated eyes (top row) compared with BSS injected eyes. Magnified section from each retina is shown in the bottom row of images. (D) Quantification of static leukocytes per mm2. The number of leukocytes was normalized by the total measured area within a 40-degree field of view centered at the optic nerve head. The number of static leukocytes was 4.2 times greater (**P < 0.01) in eyes treated with contact system (n = 5) versus BSS (n = 6) alone.
Date of download: 1/23/2018
The Association for Research in Vision and Ophthalmology Copyright © All rights reserved.