1. Development of the heart
Dr. Altdorfer
Development of the heart

2. Overview Cardiogenic plate Heart tube Devel. of the atria
Devel. of the ventricles
Aorticopulmonary septum
Malformations

3. 1. Cardiogenic plate 3. week
Cardiogenic plate (in front of the buccopharyngeal membrane), splanchnopleura
Anterior folding (4. week):

4. 1. Cardiogenic plate Lateral folding:
fusion of the endocardial heart tubes

5. 2. Heart tube
Arterial and venous ends

6. 2. Heart tube Arterial and venous ends Bulbo-ventricular loop
Transverse sinus of pericardium

7. 3. Atria – interatrial septum

8. 3. Atria
2 sources of the sources of the
right atrium left atrium

9. 3. Atria – interatrial septum
Septum spurium
(sinu-atrial junction)

10. 3. Atria – interatrial septum
Septum spurium
Eustach Thebesius

11. 4. Ventricles – interventricular septum

12. 5. Aorticopulmonary septum
Divides the bulbus cordis and truncus arteriosus → aorta + pulmonary trunk
Neural crest cells!
Endocardial swellings, cushions
Truncal ridges, bulbar ridges → spiral course

13. 5. Aorticopulmonary septum + semilunar valves

14. 6. Malformations
Situs inversus totalis
< 1:10000
Dextrocardy

15. 6. Malformations Atrial septal defects (ASD)
- ostium secundum type
- persisting foramen ovale (PFO)
Ventricularis septal defects (VSD) – usually at the pars membranacea region

16. 6. Malformations

17. „Some people say, that the heart is a paired organ”
Images:
Dr. Ádám
Dr. Lendvai
Dr. Kozsurek