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Stefan Hammerschmidt, MD, Nicole Büchler, Hans Wahn, MD  CHEST 

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Presentation on theme: "Stefan Hammerschmidt, MD, Nicole Büchler, Hans Wahn, MD  CHEST "— Presentation transcript:

1 Tissue Lipid Peroxidation and Reduced Glutathione Depletion in Hypochlorite-Induced Lung Injury 
Stefan Hammerschmidt, MD, Nicole Büchler, Hans Wahn, MD  CHEST  Volume 121, Issue 2, Pages (February 2002) DOI: /chest Copyright © 2002 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Hypochlorite-induced pressure response. Upper panel: course of the increase in PAP due continuous infusion of hypochlorite over time. Lower panel: comparison of baseline PAP (PAPt = 0 min) and PAPmax of all experimental groups (*p < 0.05 vs c-105). CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Mean total recording (ttot) and mean time of PAPmax (tpapmax) of all experimental groups are compared (*p < 0.05 vs c-105). CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Tissue concentration of rGSH and of free functional sulfhydryl (SH) groups (upper panel) and the tissue concentration of the LPO products malonaldehyde and 4-hydroxyalkenals (lower panel) of all experimental groups are shown (*p < 0.05 vs both controls). CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Parameters of lung injury, ie,Δ PAPmax (upper panels) and Kf,cmax (lower panels), of the 500 nmol/min, 1,000 nmol/min, and 2,000 nmol/min HOCl groups are plotted against the corresponding tissue rGSH concentration of each individual experiment. The left column summarizes these correlations of the data for all three groups. The correlation coefficient and its p value are given. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Parameters of lung injury, ie,Δ PAPmax (upper panels) and Kf,cmax (lower panels), of the 500 nmol/min, 1,000 nmol/min, and 2,000 nmol/min HOCl groups are plotted against the corresponding tissue LPO product concentration of each individual experiment. The correlation coefficient and its p value are given. CHEST  , DOI: ( /chest ) Copyright © 2002 The American College of Chest Physicians Terms and Conditions


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