1. NIMH Update Christopher Sarampote, NIMH 2017 AADCAP Annual Meeting
Office of Training and Career Development
Division of Translational Research
NIMH
2017 AADCAP Annual Meeting
Washington, DC

2. NIMH Extramural Scientific Divisions
Office of Research Disparities and Global Mental Health (ORDGMH)
Translational
(DTR)
Neuroscience & Basic Behavioral (DNBBS)
Services & Interventions
(DSIR)
AIDS/HIV
(DAR)
NIMH organization and where I reside
Psychopathology
Tx Development
Effectiveness
Services
Pre-Clinical

3. NIMH Transitions Leadership NIMH and HHS
New Director: Josh Gordon, MD, PhD
New Deputy Director: Shelli Avenevoli, PhD
NIMH and HHS
NIMH looks forward to working with the new administration
NIMH contributed to NIH transition reports
Dr. Collins will continue as NIH Director for an indeterminate time
Dr. Gordon’s research focuses on the analysis of neural activity in mice carrying mutations of relevance to psychiatric disease.
Was an associate director of the Columbia University/New York State Psychiatric Institute Adult Psychiatry Residency Program
Also maintained a general psychiatric practice, caring for patients who suffer from the illnesses he studied in his lab at Columbia.
Shelli Avenevoli: developmental psychologist and extramural program officer
Continuation of NIMH priorities under Dr. Insel at this time, with new priorities under evaluation and development
Directors’ messages page: autism, psychosocial intervention, computational neuroscience

4. 21st Century Cures Act (Dec 2016)
Non-partisan national commitment to mental health research, prevention, treatment, and recovery
Key provisions for mental health treatment:
Appoints directors of NIMH, NIDA, NIAAA, to SAMHSA advisory councils
Encourages collaboration to ensure evidence-based practices
Strengthens existing mental and behavioral health care parity legislation
Includes broad provisions to assist for special populations
Key provisions for mental health research:
Encourages rigor and reproducibility; strengthens NIH’s ability to enforce data sharing
Requires Certificates of Confidentiality for clinical research
Exempts certain genomic data from Freedom of Information Act requests
Signed into law December 2016
New secretary for mental health and substance abuse services in HHS: candidate Dr. Elinore McCance-Katz 

5. 21st Century Cures Act of 2016
$4.8 Billion for NIH Innovative Research Initiatives
BRAIN: Brain Research through Advancing Innovative Neurotechnologies
Reprinted from Hudson, KL and Collins, FS (2017). The 21st Century Cures Act: A View from the NIH. NEJM, 376:

6. NIH BRAIN Initiative Oct 2016: NIH announced third round of grants
Over 100 new awards
170 investigators working at 60 institutions
Totaling more than $70m
Nearly doubles FY2016 NIH investment in BRAIN
21st Century Cures Act authorizes funding for 10 more years

7. Adolescent Brain Cognitive Development (ABCD) Study
Multi-site, landmark study on brain development and child health led by NIDA, NIAAA, NCI
Will recruit 10,000 healthy children and follow into adulthood

8. NIMH Budget Updates
Approximately $980M for RPGs, $38M for research training, $172M IM, $73M research centers

9. Overview of Current NIMH Priorities
Strategic Objectives
Experimental Therapeutics Approach to Interventions
RDoC and Data-Driven Approaches
Suicide Prevention
Understanding Neural Circuits
Computational Psychiatry

10. NIMH and Clinical Neuroscience
To wrest from nature the secrets which have perplexed philosophers in all ages, to track their sources the cause of disease, to correlate the vast stores of knowledge, that they may be quickly available for prevention and cure of disease – these are our ambitions.
- Sir William Osler
Since Dr. Insel’s arrival at NIMH, the institute has increasingly focused on underlying brain circuitry that gives rise to mental illness, so that we might leverage the findings from basic neuroscience to understand etiology of disease, risk factors, and identify new treatments.

11. NIMH Research Priorities
Mission: To transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure
Strategic Objective 1: Define the mechanisms of complex behaviors
Strategic Objective 2: Chart mental illness trajectories to determine when, where, and how to intervene
Strategic Objective 3: Strive for prevention and cures
Strategic Objective 4: Strengthen the public health impact of NIMH-supported research

12. Experimental Therapeutics Approach to Interventions
as tool to validate or engage the target
Target Engagement
informs “go/”no-go” decision
Clinical Trial
value optimized regardless of clinical effect

13. Clinical Trial Pipeline: Phase of Intervention Development
Experimental Therapeutics Clinical Trials Funding Opportunity Announcements (FOAs)
Clinical Trial Pipeline: Phase of Intervention Development
First in Human
Exploratory Experimental Therapeutics
Confirmatory Efficacy
Effectiveness Trials for Treatment, Preventive, and Services Interventions
First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01)
Confirmatory Efficacy Trials of Non-Pharmacological Interventions for Mental Disorders (R01)
Pilot Effectiveness Trials for Treatment, Preventive and Serivices Interventions (R34)
Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (R61/R33, R33)
Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions
(R01, Collaborative R01)
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33, R33)

14. Research Domain Criteria (RDoC)
Dimensional approach to psychopathology that integrates elements of biology and psychology
Template for psychopathology research (NOT a classification system)
Agnostic to diagnosis, but focused on narrowly defined impairments of psychiatric clinical importance
Take home messages
This is not a classification system
Agnostic to diagnosis
Not all grants need to be RDoC grants

15. Research Domain Criteria (RDoC)
Over 40 grants funded under RDoC FOAS since 2011
Resources
NIMH RDoC webpage
RDoC monthly “Office Hours”
RDoC Webinar Series
RDoC-influenced Courses

16. Suicide Prevention

17. Behavioral Neuroscience: Understanding Neural Circuitry
Etiological Factors (genes, experience)
Molecular or Structural Pathology
Circuit Dysfunction
Neuro-functional Disability
Understanding brain function and dysfunction
Characterize molecular identity, anatomy, and activity patterns in a cell-type specific manner
Monitor and manipulate circuits for improved function
Drive and inhibit circuits with precise behavioral effects.

18. Computational Psychiatry

19. Research Training and Career Development
NIMH offers training grants across the career timeline
Three ways NIMH provides training funds
Directly from NIH (individual awards: F, K)
From an academic institution with an NIH-supported training program (T32)
From an administrative supplement to an existing NIH grant (diversity reentry, MD)
NIMH Training Success Rates: F: 20%, Mentored K: 38%, K99: 23%

20. Specific Training Opportunities
F30 NRSA Individual Predoctoral MD/PhD or other Dual-Doctoral Degree Fellowship
Administrative Supplements for Physician Scientists
NIMH Research Education Programs Supporting Psychiatry Residents (R25)
NIMH Mentoring Networks for Mental Health Research (R25)

21. Career Development Program in Emergency Care Research (K12)
Areas of interest: suicide prevention; management of psychiatric emergencies in ED settings; post-traumatic psychopathology risk detection and intervention; and mental health services in ED settings.
Recruitment of the second, and final, cohort of K12 scholars will open later in 2017
Indiana Emergency Care Research (Indiana EMCARE) Training Program
Indiana University School of Medicine
Program Directors: Jeffrey A. Kline, MD and Kurt Kroenke, MD
Oregon Emergency Care Research Multidisciplinary Training Program
Oregon Health & Science University
Program Directors:  Craig D. Newgard, MD, MPH and Cynthia D. Morris, PhD, MPH
Vanderbilt Emergency Care Research Training Program
Vanderbilt University
Program Directors:  Alan B. Storrow, MD and Thomas J. Wang, MD
NIMH Contact: Lauren Hill, PhD

22. NIH Loan Repayment Program
Repay up to $35K annually of a researcher’s qualified educational debt
Renewable

23.
Research = Hope