1. BLOOD CELLS & BLOOD TYPING

2. Hematophobia = fear of blood
Blood transports substances & maintains homeostasis in body
Hematophobia = fear of blood

3. Blood & Blood Cells Blood - type of CONNECTIVE TISSUE
2 basic components:
CELLS  (rbc, wbc, platelets)  = 45%
Plasma (water, proteins, amino acids..etc)  = 55%

4. HEMATOPOEISIS
formation of blood cells
occurs in bone marrow
Old blood cells are destroyed by liver & spleen - phagocytosis

5. EPO (erythropoietin) - hormone that increases production of RBC’s.
In the first part of a two-night interview broadcast Thursday, disgraced cyclist Lance Armstrong admitted to Oprah Winfrey that he took banned substances, including EPO, during all seven of his Tour de France victories.
What is EPO? (Gizmodo Article)

6. Hematocrit - volume of blood cells in a sample, should be 45%.
Remaining fluid is plasma (55%).
To determine %’s , blood is placed in a centrifuge
Heavier cells settle to bottom of sample.

7. PHLEBOTOMIST
person trained to draw blood from a patient for clinical or medical testing, transfusions, donations, or research.

8. PLASMA liquid portion of blood (92% water)
Also contains nutrients, gases, vitamins, & proteins

9. PART A. TYPES OF BLOOD CELLS

11. RBCs & PLATELETS

12. Seratonin = vasoconstrictor 2. Platelet plug formation
3 EVENTS IN HEMOSTASIS
1.  Blood Vessel Spasm
 Seratonin = vasoconstrictor
2.  Platelet plug formation
3.   Blood coagulation
conversion of fibrinogen to fibrin (thrombin - enzyme that causes conversion)

13. COAGULATION  -  the thickening of blood to form a clot  (hematoma)

14. THROMBUS – blood clot (abnormal)
EMBOLUS – when the clot moves to another place.
* Cerebral Embolism - when a blood clot goes to the brain
* Pulmonary Embolism - when a blood clot goes to the lungs

15. NEUTROPHIL

16. EOSINOPHIL

17. BASOPHIL

18. LYMPHOCYTE

19. MONOCYTE

21. PART B. DIFFERENTIAL WBC COUNT

22. LEUKEMIA

23. EOSINOPHILIA

24. Blood Type is Controlled by 3 Alleles
PART C. ABO BLOOD TYPING
4 Possible Blood Types
Blood Type is Controlled by 3 Alleles
Alleles: A, B, O
A & B are codominant
O is recessive

25. Genotypes Blood types Type A = AA or AO Type B = BB or BO Type AB = AB
Type O = OO
Blood types

26. Table 12.03

27. Why is O the “universal donor?
TYPE A
TYPE B
TYPE AB
TYPE O

29. Blood Type Test

30. PART D. – Rh BLOOD TYPING

32. Rh Factor
A person can either be Rh + or Rh –
(positive is dominant)

33. Erythroblastosis Fetalis

35. Dermatographia: Immune system releases excess amounts of histamine causing welts to appear when lightly scratched.
Cold Urticaria (essentially meaning "cold hives") is anywhere hives or large red welts form on the skin after exposure to a cold stimulus.