1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Mike Lin

2. NSAIDs Therapeutic Effects List of NSAIDs Anatomic Pathway Mechanism
Aspirin & Ibuprofen
Side Effects

3. Therapeutic Effects Analgesic: Reduction of pain perception
Antipyretic:
Reduction in fever
Anti-Inflammatory:
Reduction of inflammation/swelling

4. List of NSAIDs

5. Anatomic Pathway
Damaged tissue causes the release of Prostaglandins from Cyclooxygenase Enzymes:
Prostaglandins
Lipid compounds that have a hormone-like effect
Stimulate nerve endings to send pain signals to the brain via the CNS
Cyclooxygenase Enzyme (COX):
COX1 - Maintenance of gastrointestinal tract and blood platelets
COX2 - Related to inflammation and pain responses

6. Mechanism NSAIDs inhibit COX enzymes:
Aspirin irreversibly modifies COX enzymes to no longer function
Ibuprofen competitively blocks substrate binding sites on enzymes
Aspirin Ibuprofen

7. Aspirin

8. Ibuprofen

9. Side Effects Blood thinning due to lack of blood clotting
Stomach ulcers from degradation of stomach lining
Kidney failure from prolonged use

10. Summary NSAIDs - Nonsteroidal Anti-Inflammatory Drugs
Reduce PAIN, FEVER, and INFLAMMATION
Function by inhibiting COX Enzymes from producing Prostaglandins
Chronic overuse can lead to serious health issues and damage