1. Efficacy and safety of dapagliflozin in patients with type 2 diabetes and concomitant heart failure 
Mikhail Kosiborod, Ingrid Gause-Nilsson, John Xu, Christian Sonesson, Eva Johnsson 
Journal of Diabetes and Its Complications 
Volume 31, Issue 7, Pages (July 2017)
DOI: /j.jdiacomp
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Fig. 1
Mean change from baseline in HbA1c, weight, and systolic blood pressure over time. *Pooled data from five studies ≤52weeks (NCT , NCT , NCT , NCT , NCT ); †Pooled data from two studies ≤52weeks (NCT , NCT ). Data based on longitudinal repeated-measures models, excluding data after rescue therapy for inadequate glycemic control (HbA1c, weight) or change in medication affecting blood pressure (SBP). Adj, adjusted; BL, baseline; CI, confidence interval; DAPA, dapagliflozin; SBP, systolic blood pressure.
Journal of Diabetes and Its Complications  , DOI: ( /j.jdiacomp )
Copyright © 2017 Elsevier Inc. Terms and Conditions

3. Fig. 2
Mean change from baseline in estimated glomerular filtration rate over time. Pooled data from five studies ≤52weeks. N is the number of randomized patients who received ≥1 dose of study medication. Includes data after rescue therapy. BL, baseline; DAPA, dapagliflozin; SD, standard deviation.
Journal of Diabetes and Its Complications  , DOI: ( /j.jdiacomp )
Copyright © 2017 Elsevier Inc. Terms and Conditions

4. Fig. 3
Percentage of patients moving by ≥1 category between normoalbuminuria*, microalbuminuria†, and macroalbuminuria‡ from baseline to Week 24. Includes data after rescue therapy. Pooled data from five studies are based on a 24-week double-blind treatment period. *UACR of 0–<30mg/g; †UACR of 30–<300mg/g; ‡UACR ≥300mg/g. §Patients shifting from micro- to normoalbuminuria or from macro- to micro- or normoalbuminuria (DAPA, n=62; Placebo, n=51). #Patients shifting from normo- to microalbuminuria or from normo- or micro- to macroalbuminuria (DAPA, n=158; Placebo, n=143). DAPA, dapagliflozin; UACR, urine albumin-to-creatinine ratio.
Journal of Diabetes and Its Complications  , DOI: ( /j.jdiacomp )
Copyright © 2017 Elsevier Inc. Terms and Conditions