1. Varicella Zoster Virus: Clinical Manifestations
Taylor Wofford
March 8, 2010

2. Human herpesviridae family
HHV-1: Herpes simplex virus -1
HHV-2: Herpes simplex virus -2
HHV-3: Varicella zoster virus
HHV-4: Ebstein-Barr Virus
HHV-5: Cytomegalovirus
HHV-6: Roseolovirus, herpes lymphotropic virus
HHV-7: Roseolovirus
HHV-8: Kaposi’s sarcoma-associated virus

3. Secondary Manifestations
Rash: papulesvesicles (dermatomal)
Acute neuritis
Zoster sine herpete ?
Postherpetic neuralgia
Herpes zoster ophthalmicus
Acute retinal necrosis
Ramsay Hunt Syndrome (herpes zoster oticus)
Aseptic meningitis
Encephalitis
Peripheral motor neuropathy
Myelitis
Stroke syndromes
Disseminated VZV

5. Treatment Acyclovir IV Valacyclovir (Valtrex) po
Best within 48 hrs of rash
Foscarnet IV
Prevention: varicella vaccine (Varivax, 1995), shingles vaccine (Zostavax, 2006)

7. Bibliography Up to Date
Herpes zoster ophthalmicus with Hutchinson sign. Image courtesy of C. Stephen Foster, MD, Massachusetts Eye Research and Surgery Institute, Harvard Medical School.
R. Meher, S. Varshney, P. Gupta & R. Srivastava : Herpes Zoster Oticus With Ménière's Syndrome Complex . The Internet Journal of Otorhinolaryngology Volume 4 Number 2