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Varicella Zoster Virus: Clinical Manifestations
Taylor Wofford March 8, 2010
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Human herpesviridae family
HHV-1: Herpes simplex virus -1 HHV-2: Herpes simplex virus -2 HHV-3: Varicella zoster virus HHV-4: Ebstein-Barr Virus HHV-5: Cytomegalovirus HHV-6: Roseolovirus, herpes lymphotropic virus HHV-7: Roseolovirus HHV-8: Kaposi’s sarcoma-associated virus
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Secondary Manifestations
Rash: papulesvesicles (dermatomal) Acute neuritis Zoster sine herpete ? Postherpetic neuralgia Herpes zoster ophthalmicus Acute retinal necrosis Ramsay Hunt Syndrome (herpes zoster oticus) Aseptic meningitis Encephalitis Peripheral motor neuropathy Myelitis Stroke syndromes Disseminated VZV
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Treatment Acyclovir IV Valacyclovir (Valtrex) po
Best within 48 hrs of rash Foscarnet IV Prevention: varicella vaccine (Varivax, 1995), shingles vaccine (Zostavax, 2006)
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Bibliography Up to Date
Herpes zoster ophthalmicus with Hutchinson sign. Image courtesy of C. Stephen Foster, MD, Massachusetts Eye Research and Surgery Institute, Harvard Medical School. R. Meher, S. Varshney, P. Gupta & R. Srivastava : Herpes Zoster Oticus With Ménière's Syndrome Complex . The Internet Journal of Otorhinolaryngology Volume 4 Number 2
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