1. Example of the storage location of the sample folder
Attention
The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM.
As shown below, sample data are normally stored in the folder of your choice.
e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA
Example of the storage location of the sample folder

2. Demonstration of Initial Assessment Using AIST-MeRAM
　Risk Assessment by Initial Mode
Get a sense of what you can do with AIST-MeRAM
Practice: Repeat the steps following the handouts and sample data

3. Initial assessment Exposure Assessment Hazard Assessment Risk
2012/8/31
Initial assessment
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management
Screening-level risk assessment
TierⅠof primary risk assessment

4. Initial assessment (exposure assessment) Step 1/7
Select “Initial
Assessment”
Select “Create New File”
Select “Exposure Assessment” in Assessment Steps.

5. Initial assessment (exposure assessment) Step 2/7
Select the sample substance for initial assessment.

6. Initial assessment (exposure assessment) Step 3/7
Select an assessment method for initial assessment

7. Initial assessment (exposure assessment) Step 4/7
Upload a list of CSCL notification information for initial assessment.
The list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

8. Initial assessment (exposure assessment) Step 5/7
List of uploaded
information

9. Initial assessment (exposure assessment) Step 6/7
Confirm assessment setting.

10. Initial assessment (exposure assessment) Step 7/7
Exposure assessment result for 4-Nonylphenol
Total emission amount and exposure class
Emission amount by life cycle stage & usage

11. Initial assessment Exposure Assessment Hazard Assessment Risk
2012/8/31
Initial assessment
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management
Screening-level risk assessment
TierⅠof primary risk assessment

12. Initial assessment (exposure assessment) Step 1/9
Select “Reassess” in the result sheet of the previous exposure assessment.
As you go back to the “Confirm” window, select “Assessment Model” in the left pane.

13. Initial assessment (exposure assessment) Step 2/9
As you go back to this window, change the assessment model to “Tier Ⅰof Primary Risk Assessment”.

14. Initial assessment (exposure assessment) Step 3/9
Select methods for estimating the emission amount.

15. Initial assessment (exposure assessment) Step 4/9
Upload a list of CSCL notification information for initial assessment.
The list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

16. Initial assessment (exposure assessment) Step 5/9
List of uploaded
information

17. Initial assessment (exposure assessment) Step 6/9
Enter physical property data

18. Initial assessment (exposure assessment) Step 7/9
Select the environmental data for the exposure scenarios.

19. Initial assessment (exposure assessment) Step 8/9

20. Initial assessment (exposure assessment) Step 9/9
Estimated exposure concentrations (PEC) by life stage and use category
Data settings registered/entered by users
Emission factors and default environmental parameters

21. Initial assessment Exposure Assessment Hazard Assessment Risk
2012/8/31
Initial assessment
Exposure
Assessment
Hazard
Assessment
Risk
Assessment
Risk
Management

22. Initial assessment (hazard assessment) Step 1/8
2012/8/31
Initial assessment (hazard assessment) Step 1/8
Go back to the Assessment Steps window by clicking the red square button.
Select “Hazard
Assessment”.
Select “Create
New File”

23. Initial assessment (exposure assessment) Step 2/8
Select the sample substance for initial assessment.

24. Initial assessment (hazard assessment) Step 3/8
Select toxicity test databases used for hazard assessment.

25. Initial assessment (hazard assessment) Step 4/8
Description of the assessment methods.

26. Initial assessment (hazard assessment) Step 5/8
Select a reliability level of toxicity data for hazard assessment.

27. Initial assessment (hazard assessment) Step 6/8
UFs are automatically determined by the method you select below, based on the availability of toxicity data.

28. Initial assessment (hazard assessment) Step 7/8
Check data/output settings.
Hazard assessment using hazard quotient
Hazard assessment using CSCL screening

29. Initial assessment (hazard assessment) Step 8/8
Hazard assessment using hazard quotient method
Hazard assessment using CSCL screening method
PNEC and uncertainty factor
Hazard class, PNEC, and uncertainty
Toxicity data
Toxicity data

30. Initial assessment (risk assessment )
2012/8/31
Initial assessment (risk assessment )
Hazard
Assessment
Exposure
Assessment
Risk
Assessment
Risk
Management

31. Initial assessment (risk assessment) Step 1/6
Select “Risk Assessment” in Assessment Steps.
Go back to the Assessment Steps window by clicking the red square button.
Select “Create
New File”

32. Initial assessment (risk assessment) Step 2/6
List of possible risk assessment combinations (hazard and exposure assessment results) is automatically displayed by the tool.

33. Initial assessment (risk assessment) Step 3/6
Risk assessment results for the sample substance are displayed.

34. Initial assessment (risk assessment) Step 4/6
Result shown as a Priority Assessment Chemical Substance
Priority matrix of CSCL

35. Initial assessment (risk assessment) Step 5/6
Risk assessment results shown as MOE
MOE>UF No risk
MOE<=UF Have risk
MOE>UF
MOE<UF

36. Initial assessment (risk assessment) Step 6/6
Result sheet of risk assessment by combination of “hazard quotient” and “risk assessmentⅠunder CSCL”.
Result shown as MOE
MOE>UF No risk
MOE<=UF Have risk
MOE>UF
MOE<UF

37. Initial assessment (risk management)
Hazard
Assessment
Exposure
Assessment
Risk
Assessment
Risk
Management

38. Initial assessment (risk management) 1/3
Select “Risk Management” in Assessment Steps.
Go back to the Assessment Steps window by clicking the red square button.

39. Initial assessment (risk management) 2/3
Select a risk assessment result file for risk management
Select “Risk management options” for
risk management

40. Initial assessment (risk management) 3/3
Finish
Yes No
Finish

41. Example of the storage location of the sample folder
Attention
The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM.
As shown below, sample data are normally stored in the folder of your choice.
e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA
Example of the storage location of the sample folder