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Inhomogeneous Tissue Studies for Clinical Proton Therapy: Universal Scaling and Interfacial Buildup Effects D. Fry1,2, Ph.D., W. Sewchand2, Sc.D. and.

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Presentation on theme: "Inhomogeneous Tissue Studies for Clinical Proton Therapy: Universal Scaling and Interfacial Buildup Effects D. Fry1,2, Ph.D., W. Sewchand2, Sc.D. and."— Presentation transcript:

1 Inhomogeneous Tissue Studies for Clinical Proton Therapy: Universal Scaling and Interfacial Buildup Effects D. Fry1,2, Ph.D., W. Sewchand2, Sc.D. and J. O’Connell2, MD 1The Henry Jackson Foundation for The Advancement of Military Medicine 2Walter Reed Army Medical Center Department of Radiation Oncology Washington, DC 20307 September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

2 Computing at Walter Reed
Master Node Cluster Node Number of Units 1 5 Number of Processors 2 (10 total) Processor Type G5, 64-bit Processor Speed 2.5 GHz (4.5 GHz Intel) RAM 1GB/processor 512MB/processor September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

3 Characterizing % Depth-Dose
Investigate properties of the clinical proton depth-dose in homogeneous and inhomogeneous materials. For quality assurance measures we need to understand properties of dose in heterogeneous structures. September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

4 Experimental Validation
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

5 Material-Dependent Scaling?
Analogy to heavy ion scaling in foil strippers : What is Z for a compound? (1) Mean Z (2) Ratio of Moments (3) Power law - photoelectric cross section September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

6 Distal Edge Width September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

7 Lateral Penumbra September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

8 Bragg Peak FWHM September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

9 Peak-to-Entrance Dose Ratio
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

10 Bone-H2O Interface Effects
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

11 Relative Energy Loss From Bone
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

12 Particle-Specific Energy Deposition
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

13 Composite Distal Edge September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

14 Composite FWHM September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

15 Future Work Phantom Development - CTSim and 3d Rapid Prototyping (collaboration with the WRAMC 3D Medical Applications Center, Dr. Erge Edgu-Fry). Full 3d heterogeneity corrections. September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

16 Integrated Dose Fraction
September 16, 2018September 16, 2018 The Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD Radiation Oncology, Walter Reed Army Medical Center, Washington, DC 20307

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