1. Supplementary Figure 1 (log fold change relative to untreated control)
Fenretinide (3µM, 8h)
Untreated
DR5
DcR2
FAS
DR4
DcR1 1 3 5 2 4
DR5 10 8 6 4
DcR2
(log fold change relative to untreated control)
Apoptosis-related gene expression 2
DR4
DcR1
Caspase-8
TRAIL
FADD
FAS
FasL
Caspase-10
c-FLIP -2 -4 1 10 20 30 40 50 60 70 80 90
100
Array position

2. Supplementary Figure 2 *

3. (% of untreated control)
Supplementary Figure 3 *
(% of untreated control)
Viable cell number

4. Fenretinide & TRAIL (24h)
Supplementary Figure 4 *
Fenretinide & TRAIL (24h)
Fenretinide
Untreated
TRAIL 6%
68%
Jurkat untreated
Jurkat etoposide 4%
62%
Cell number
Caspase-8 cleavage 9%