3. Liver only transplants in the UK

4. Question 2: In terms of survival benefit

6. 2915 (81%) deceased donor after brain death (DBD) liver transplants
Data from UK Transplant Registry (UKTR)
Transplant survival: composite outcome of graft and patient survival
Conditional analysis on patients surviving at 30 and 90 days
3575 first elective adult NHS group 1 orthotopic liver only txs from deceased donor
2915 (81%) deceased donor after brain death (DBD) liver transplants
660 (19%) donor after circulatory death (DCD) liver transplants
1 January 2006 to 31 December 2013
Three end points post-transplant considered separately
30 days, 1 and 5 years
Univariate transplant survival estimates obtained using Kaplan-Meier estimation method
survival compared using log-rank test
Multivariate Cox regression analysis performed to identify factors associated with transplant survival
time from liver transplant to earlier of graft failure or patient death (deaths with a functioning graft included as events)

7. Note: ABO match, time to transplant and donor BMI influential at 30 days but not later on. Donor age influential in the long term

8. DBD survival ~ 80% at 5 years DCD survival ~ 70% at 5 years
Waiting list survival ~ 40% at 5 years
Left panel: Survival post transplant. Events: graft failure or patient death, the earliest of the two
Cohort:
3575 first elective adult NHS group 1 orthotopic liver only txs from deceased donor
2915 (81%) deceased donor after brain death (DBD) liver transplants
660 (19%) donor after circulatory death (DCD) liver transplants
1 January 2006 to 31 December 2013
Right panel: Survival post registration. Events: patient death
5071 first, adult, elective liver only registrations in the UK

10. Size: +- 20 kg in donor-recipient match
Blood group compatibility: O donor can go to any recipient; A donor can only go to groups A or AB; B donor can only go to group B or AB; AB donor can only go to group AB.

12. Emphasise that this is a different cohort than before
Emphasise that this is a different cohort than before. These are registrations whereas, previously, looking at transplants

14. Benefit conclusion: It is possible that the HR under- or over-estimates the effect of DCD liver tx for certain patient subgroups