1. African Capacity Development needs Alioune DIEYE, EDCTP-DCCC Chair Consensus meeting of the EDCTP-II Brussels, 27-28 September 2010

2. Overall goal The programme objective is to accelerate the development of new or improved drugs, microbicides, diagnostics and vaccines against these diseases, currently with a focus on phase II and III clinical trials and on sub-Saharan Africa.

3. EDCTP II JPA Activity areas 1. Networking; N/N, N/S 2. South Networking 3. Clinical trials 4. Capacity building in DC 5. Advocacy and Fundraising 6. Programme Management 7. Information management and databases

4. Developing Countries Coordinating Committee (DCCC) Chairperson : Prof. Alioune DIEYE (Senegal) Vice-Chairperson : Dr Veronique Penlap (Cameroon) Second Vice-Chairperson: Prof. Nkandu Luo (Zambia) Dr Martin Antonio (Ghana) Dr Modest Mulenga (Zambia) Dr. Jasper Ogwa-Okeng (Uganda) Prof. Angelique Ndjoyi Mbiguino (Gabon) Dr Abraham Alabi (Nigeria) Prof. Mecky Matee (Tanzania) Dr Issoufu Saadou(Benin) Dr Omu Anzala (Kenya) Dr Hulda Swai (Tanzania) Representatives from: OCEAC, WAHO, WHO AFRO, SADEC

5. 3 Main pillars 1.Human Resources 2. South –South Networking 3. Research Institutions and Health services environments

6. Specific Capacity Development objectives Upgrade sites including training for specific staff Training (Masters and PhD students) as well as Postdoctoral and Senior Fellows Retention of highly skilled very senior scientists and encouraging the return of those in the Diaspora Improve compliance with internationally accepted standards for ethical review, drug regulatory authorities Support the establishment of regional nodes of excellence, the development and site characterisation studies.

7. What are the proposed strategies to implement the 3 pillars?

8. 1. HUMAN RESOURCES: TRAINING AND FELLOWSHIPS

9. Human Resources :Training Staff working on clinical trial sites : IT staff, Clinical Monitors, Financial managers, Project managers, personnel involved with patients or patient material, community representatives and laboratory personnel.

10. Human Resources : Fellowships Senior Fellowships Postdoctoral Fellowships: part of the capacity development work package of integrated projects Advanced Fellowship and Mentorship for very senior scientists

11. 2. SOUTH-SOUTH NETWORKING

12. South-South Networking Support the Regional Networks of Excellence (NoEs): Regional reference laboratories Centres specialised in Data management Support the development and site characterisation studies: Lack of recent epidemiological data

13. 3. RESEARCH INSTITUTIONS AND HEALTH SERVICES ENVIRONMENTS

14. Improvement of Research Institutions and Health Services environments Establishment and strengthening of national ethical committees (NEC) Creation and strengthening of Institutional Review Committees (IRC) Supporting the strengthening of National Regulatory Bodies/Agencies in Africa through collaboration with WHO initiatives.

15. Improvement of Research Institutions and Health Services environments Sustaining adequate scientific capacity of Institutions (Infrastructure requirements) Promoting the strengthening of Health services Research on the application of products in health services and disease control programmes, with studies on pharmacovigilance, delivery or accessibility and controlled community-based interventions

16. EDCTP public Consultancy: The University of Oxford There is a vast gap in capacity to run trials between the developed and developing world. Currently over 90% of trials conducting in these regions are sponsored by northern partners. In practice this means that most of the scientific input and thinking being conducted by the sponsor and the trial sites merely operate the study. Sites are not left with skills to run their own programmes. Often capacity building is attached to these studies as window dressing.

17. Thank you!