1. Endocrine Combinations in HR-Positive MBC: The Future Is Now

3. Program Overview

4. Treatment Challenges in Postmenopausal Patients With HR+ Advanced Disease

5. Algorithm for Management of Postmenopausal ER+ MBC

6. Visceral Crisis

7. Combined ET Results

8. Sequential Use of ET for Advanced Breast Cancer

9. Phase 2 FIRST Trial: Fulvestrant vs Anastrozole for Advanced Breast Cancer

10. FALCON: Study Design

11. PALOMA-1: Study Design

12. PALOMA-1: PFS (ITT Population)

13. PALOMA-1: All-Causality AEs Occurring in ≥10% of Patients (Safety Population)

14. PALOMA-2: Study Design

15. PALOMA-3: Study Design

16. PALOMA-3 Results

17. The PI3K Pathway in Breast Cancer

18. BELLE-2: Buparlisib Plus Fulvestrant in Advanced HR+ Disease

19. Monotherapy vs Combination Therapy

20. Ongoing Clinical Questions

21. Conclusions

22. Abbreviations

23. Abbreviations (cont)