1. 4 Chapter 4: Chromosome 4 A Cell Nucleus 2,936 604217 aa SLC34A2
DNA Sequence
Chromosome 4
2,936
Name of Protein
Name of Gene
pH-sensitive sodium
SLC34A2
transcription
Amino acid sequence
mRNA aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.
Condition/Disease
pulmonary alveolar microlithiasis

2. Description of polycystic kidney disease
Symptoms and characteristics
Polycystic kidney disease is a genetic disorder characterized by the growth of numerous cysts in the kidneys.
Kidney Stones
High blood pressue
Blood in urine (hematuria)
Kidney Stones
Kiney Stones in a person

3. Description of polycystic kidney disease (cont.)
Who is affected? Anyone, but the following have a higher risk:
Any one
Outlook or quality of life
Doctors appointments
Healthy diets
Life expectancy 30 if not healthy 90 if healthy with the dieses.
Researcher: HP

4. References http://www.ncbi.nlm.nih.gov/gene/5311