1. Benefits of apheresis collection
© 2012 Haemonetics Corp COL-COPY (AA)

2. Content Trends in blood collection Donor recruitment
Benefits of apheresis
Efficiency
Standardization
Cost-efficiency
Patient safety
Management of stock
Quality

3. Trends in blood collection
Shortage of targeted blood types & components
Increase of blood production costs
New technologies, instruments
Shrinking donor base
Health issues
Social attitudes
Selection criteria
Increased Demand for components
Europe is predicting shrinking demand for Red Cells, but there is an imbalance of blood groups and specific blood types collected vs. needed.- so that there are blood group / blood type specific shortages
Shrinking Donor Base- Gen X isn’t as community Oriented as past generations –True for Europe as well.- an aging donor population
Fast Paced Society- time is of the essence
Cost Containment- competing blood banks in some areas. Low RC price in some EU countries
Technological Advancements
Regulatory Issues
Decreased errors in documentation due to automation of data collection and data entry – improvement in compliance and audits
Testing is done from one set of samples for both units thereby decreasing the cost of testing in half .

4. Possible ways to respond
Donor recruitment
Implement more efficient methods for donation
Apheresis!

5. Increase the donor recruitment efforts
Donor recruitment is very costly in marketing campaign and resources.
A UK (NBS) study demonstrated that in order to just slightly increase the donor population, recruitment costs would have to exponentially grow.
Increase the donor recruitment efforts
Costs
Additional donors
Baseline
Aging donor population
Decreased willingness to donate
New, more stringent guidelines

6. Benefits of apheresis Efficiency Standardization Cost-efficiency
More components per donor
Standardization
Better consistency in volume, yield, product quality
Cost-efficiency
Reduce lab cost, testing costs
Patient safety
Reduce exposition to multiple donors
Management of stock
Improve stock management by collecting product needed
Quality
Improve blood center management

7. Efficiency
2 Whole blood donors
1 2RBC &
1 RBCP donor
2 2RBC donors

8. Efficiency Platelets can be collected in different ways:
Whole blood donation
Platelet apheresis
1 unit Platelets (0.5x1011)
6-12 units Platelets (3-6x1011) +
1 unit Plasma + 1 unit RBC or
6 units Platelets +
2 unit Plasma
1 unit RBC

9. Standardization
Apheresis collection allows the production of blood components of high quality and in standardized quantities
Automated production
Products ready to use
Standardized products and processes
In-line filtration
WB RBC
Apheresis RBC
± 12% Variation
Haemonetics' internal study, [n = 352].
± 6% Variation
Improved red blood cell products: collection by apheresis. Smith JW, Axelrod FP, Ness PM. AABB Abstract #S263, [n = 1,612]

10. Apheresis derived products show better in vitro quality
In- vitro (laboratory) study compares biochemical and functional properties of platelets and plasma coagulation factors in buffy coat-derived platelet concentrates (PCs) and apheresis derived platelet concentrates (APCs) over a storage period of 7 days at 20-24oC under constant agitation (52 rpm)
7 days storage
Apheresis
Buffy coat
P-Selectin (ngmL-1)
105
362
LDH (µMS-1)
4.3
24.4
LDH = lactate dehydrogenase is a marker of a stressed platelet
P-Selectin is a platelet activation marker
Source: M. Böck, S.Rahrig Transfusion 2002;12:

11. Apheresis collections are safe
Procedure n
Moderate
rate/10,000
Severe
Chi Square
Whole blood
826,378
14.47
1.5
Plateletpheresis
72,464
6.21
1.1
WB v. Plt-pheresis and Automated RBC
6.27E -07
Automated RBC
59,995
6.83
1.16
Platelet v. Automated RBC 0.465
Automated collection of RBC as safe or safer than manual collection.
2-RBC or RBC-P: Moderate & Severe reactions
Source: T. Wiltbank, Transfusion 2002;42:67S,SP137

12. Cost-efficiency It benefits the ratio cost-effectiveness
by collecting more products from the same donor
by reducing the testing costs
by reducing the processing and laboratory work

13. Patient safety Improve the patient safety
Reduce risks linked to pooled products (platelets)
Reduce risks linked to residual plasma in platelets (concentrated platelets)
Minimize the exposure to multiple donors (using highly repeat donors and guaranteeing the pureness and quality of the components)
Reduce risk of bacteriologic contamination during the lab process.

14. Management of stock
Multicomponents apheresis collections improve stock management by collecting products needed.

15. Management of stock Strategy Donation type Donors RBC units Plt units
FFP units
Whole Blood
100
1. Less
donors 30
2RBC 60
Plasma 22 66
SDP 2 12 4
LDPRBC 10
Total 1
94 (-6%)
102
2. More
platelets 20
Total 2
150 (+50%)

16. Management of stock Adopt type of donation to donor profile
Supply meets demand
Adjust blood type specific shortages and surpluses
Optimize collection efficiency for given donor population
Type of donation
Blood type
% of donors
Platelets, WB A
43%
2RBC, RBCP, WB B
11% O
41%
FFP, Platelets, RBCP AB 5%

17. Quality
Usage of apheresis devices improves blood center management (SOP’s, data management, GMPs)

18. Thank you for your attention