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Conjunctival malignant melanoma: A rare variant and review of important diagnostic and therapeutic considerations  Danah H. Albreiki, MD, FRCSC, Steven.

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Presentation on theme: "Conjunctival malignant melanoma: A rare variant and review of important diagnostic and therapeutic considerations  Danah H. Albreiki, MD, FRCSC, Steven."— Presentation transcript:

1 Conjunctival malignant melanoma: A rare variant and review of important diagnostic and therapeutic considerations  Danah H. Albreiki, MD, FRCSC, Steven M. Gilberg, MD, FRCSC, James P. Farmer, MD, FRCPC, FRCSC  Saudi Journal of Ophthalmology  Volume 26, Issue 2, Pages (April 2012) DOI: /j.sjopt Copyright © Terms and Conditions

2 Figure 1 High power view of the nodule in the substantia propria demonstrating the signet ring morphology (eccentric hyperchromatic nuclei and prominent amphophilic cytoplasm). Note the occasional but infrequent cytoplasmic pigment. (hematoxylin and eosin stain, 400×). Saudi Journal of Ophthalmology  , DOI: ( /j.sjopt ) Copyright © Terms and Conditions

3 Figure 2 Immunohistochemical stain PanMel highlighting the extent of (PAM) in the conjunctival epithelium overlying the tumor (200×). Saudi Journal of Ophthalmology  , DOI: ( /j.sjopt ) Copyright © Terms and Conditions

4 Figure 3 Immunohistochemical stain PanMel highlighting the strong cytoplasmic positivity of the signet ring cells for the combined melanocytic markers in the PanMel stain (400×). Saudi Journal of Ophthalmology  , DOI: ( /j.sjopt ) Copyright © Terms and Conditions

5 Figure 4 Immunohistochemical stain PanMel highlighting the extent of PAM in the conjunctival epithelium away from the tumor (200×). Saudi Journal of Ophthalmology  , DOI: ( /j.sjopt ) Copyright © Terms and Conditions

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