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Matrix Metalloproteinases and Their Tissue Inhibitors in Cardiac AmyloidosisCLINICAL PERSPECTIVE
by Andreia Biolo, Sujata Ramamurthy, Lawreen H. Connors, Carl J. O'Hara, Hans K. Meier-Ewert, Pamela T. Soo Hoo, Douglas B. Sawyer, David S. Seldin, and Flora Sam Circ Heart Fail Volume 1(4): November 1, 2008 Copyright © American Heart Association, Inc. All rights reserved.
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Figure 1. BNP and the ECM proteolytic marker profile in cardiac and noncardiac amyloidosis.
Figure 1. BNP and the ECM proteolytic marker profile in cardiac and noncardiac amyloidosis. A, BNP; B, TIMP-1; C, MMP-9; D, TIMP-2; E, TIMP-4; F, MMP-2. *P=0.01 versus AL-renal; †P<0.01 versus SSA-ATTR; **P<0.05 versus AL-renal; ‡P<0.05 versus SSA-ATTR. Andreia Biolo et al. Circ Heart Fail. 2008;1: Copyright © American Heart Association, Inc. All rights reserved.
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Figure 2. The relationship between BNP and MMP-9 (A), TIMP-1 (B), MMP-2 (C), and MMP-9/TIMP-1 (D).
Figure 2. The relationship between BNP and MMP-9 (A), TIMP-1 (B), MMP-2 (C), and MMP-9/TIMP-1 (D). Closed squares indicate AL-CMP; open squares, SSA-ATTR group. Andreia Biolo et al. Circ Heart Fail. 2008;1: Copyright © American Heart Association, Inc. All rights reserved.
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Figure 3. The relationship between tissue Doppler e′ and BNP (A), TIMP-1 (B), and MMP-9 (C).
Figure 3. The relationship between tissue Doppler e′ and BNP (A), TIMP-1 (B), and MMP-9 (C). Closed squares indicate AL-CMP; open squares, SSA-ATTR group. Andreia Biolo et al. Circ Heart Fail. 2008;1: Copyright © American Heart Association, Inc. All rights reserved.
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Figure 4. Immunohistochemical analyses of MMP-9 and TIMP-1 in amyloidotic endomyocardial biopsy.
Figure 4. Immunohistochemical analyses of MMP-9 and TIMP-1 in amyloidotic endomyocardial biopsy. A, There is no MMP-9 staining in the normal, nonamyloid heart. MMP-9 expression is more diffuse in AL-CMP than SSA heart biopsies. Solid blue arrows indicate amorphous amyloid deposition in the ECM. (Magnification ×100.) B, MMP-9 expression in AL-CMP and SSA heart biopsies. Solid black arrows indicate staining in cardiomyocytes; dashed back arrows, MMP-9 staining in the interstitium; red arrows, MMP-9 expression in (+) control; blue arrows, amyloid deposits in the ECM. (Magnification ×400.) C, TIMP-1 expression is more diffuse in AL-CMP than SSA heart biopsies. Solid arrows indicate TIMP-1 staining in cardiomyocytes; dashed arrows, TIMP-1 staining in the interstitium; red arrows, TIMP-1 expression in (+) control; blue arrows, amyloid deposition in the ECM. (Magnification ×400.) Andreia Biolo et al. Circ Heart Fail. 2008;1: Copyright © American Heart Association, Inc. All rights reserved.
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