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Complex trait analysis beyond QTL mapping webqtl.org

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Presentation on theme: "Complex trait analysis beyond QTL mapping webqtl.org"— Presentation transcript:

1 Complex trait analysis beyond QTL mapping www.webqtl.org webqtl.org

2 WebQTL Analysis

3 WebQTL Components WebQTL pages (Python)
Phenotype & Genotype data (MySQL) QTL mapping & Correlation (C)

4 Search BXD trait data

5 Search results

6 Analysis selection window

7 Genome-wide QTL mapping

8 Analysis selection window

9 Correlation search results

10 Multiple probe choice

11 Mutiple probe: single chromosome

12 Tutorial

13 Choice is good Stein, L (2002) Creating a bioinformatics nation. Nature 417,

14 cmd=get&probeset=101741_at&db=1&probe=all&format=col
Trait data retrieval cmd=get&probeset=101741_at&db=1&probe=all&format=col

15 Trait data formatted in rows
cmd=get&probeset=101741_at&db=1&probe=all&format=row

16 Genotype data in columns
cmd=geno&riset=BXD&chr=1&format=col

17 Single marker QTL mapping
cmd=map&probeset=99856_r_at&db=1&sort=lrs&return=20

18 Peak LRS from interval mapping
cmd=interval&probeset=99856_r_at&db=1&sort=pos&return=10

19 Scripted mapping and data retrieval

20 What WebQTL is not Detail
P-value plot of every 10th from 195,327 values Detail

21 Acknowledgements Genotype/Genomic data Lu Lu Jing Gu
Shuhua Qi John Hogenesch Timothy Wiltshire Yanhua Qu Brain expression data Siming Shou John Mountz HuiChen Su David Threadgill HSC expression data Gerald de Haan Michael Cooke Leonid Bystrykh Ellen Weersing Bert Dontje Andrew Su Cerebellum expression data UTHSC-St Jude Cerebellum Consortium Vision and Motivation Robert W Williams Web site design & coding Jintao Wang Kenneth F Manly Alex G Williams Published phenotype data Elissa S Chesler John C Crabbe John K Belknap Byron Jones Ryan McNieve Nathan Copeland


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