1. The HVTN is supported through a cooperative agreement with the National Institute of Allergy and Infectious Diseases HVTN 505 Lessons learned in year 1 Niles Eaton, MPH Manager, Community Education Unit HVTN Core Operations Center Draft – 12 Nov 2010

3. HIV Vaccine trials in US MSM at high risk

4. Where are we now?

5. HVTN 505 enrollment, an iterative process Version 2.0 approved: risk criteria simplification & specific language on transgender Initial Core-generated materials available Amendment: upper age limit elevated to 50 Rapid needs assessment of all sites Site expansion process

6. Strategies Initiated by HVTN Core: May 2010 Working Only So-So Not Working N/AIn Process (TBD) Hope Takes Action web contacts361 Facebook Ads12331 Banner ads on hook-up websites 12 7 Twitter5 41 Media stories initiated by HVTN Core 3 6 1 Transit advertising (bus, train, etc.)2314 Bus bench/shelter ads1234 Phone kiosk ads19 Print ads in local paper(s)4231 Hope Takes Action Posters 22 5 1 Hope Takes Action Palm cards2521 Hope Takes Action Post Cards1522 Hope Takes Action small poster w/ tear-off pads 22 5 1 Hope Takes Action drink coasters 21 7 Hope Takes Action give-away items: Condoms343 Hope Takes Action give-away items: Bags433 Hope Takes Action give-away items: Lip Balm5 32 Hope Takes Action give-away items: Yo-Yos7 12 Hope Takes Action give-away items: Gum8 11 Hope Takes Action give-away items: Hand Sanitizer6 22 Other give-aways (rubber duckies, etc.)118 Cling ads for bathroom posting 1 7 2 Hope Takes Action table tents1342 T-shirts for recruiters3322 Not Working: -Banner ads on hook-up sites -Twitter -Media stories generated by HVTN Core -Hope Takes Action: - Action Posters - Small posters with tear offs - Coasters - Cling ads Working: -Hope Takes Action give-aways Lip Balm Yo-yos Gum Hand Sanitizer

7. Survey of HVTN 505 sites, May 2010 Referral Source: ScreenedEnrolled Bar/Street/Other Outreach312 66 (38%) Internet39840 (23%) Core placed ads15310 (6%) Site placed ads/flyers35423 (13%) Other (referrals, rollovers, unk)24030 (18%) To be classified282 (<1%) 1485171 *missing: Birmingham, Los Angeles, VRC

8. Survey of HVTN 505 sites, Sep 2010 Referral Source: ScreenedEnrolled Bar/Street/Other Outreach576 145 (39%) Pride activities49 6 (<1%) Internet33480 (22%) Core placed ads14423 (6%) Site placed ads/flyers24546 (12%) Other (referrals, rollovers, unk)25767 (18%) To be classified13 (<1%) Total1606370

9. CEU & Legacy Project staff Site Visits Main objective: assess recruitment & screening process for any obvious gaps Collect & disseminate best practices Provide recommendations Report to Community Affairs & Site Assistance Working Group (CASA) for additional review & feedback

10. HVTN 505 branding: evolution & customizing

11. Web & social media: generating contacts New campaigns launched Changed Facebook ad targeting

12. Site developed brands & materials

13. Summary of lessons learned It can take time for the community to respond to a study starting up Make materials available prior to study start, or plan on lead-in period Evaluate, tweak & refresh strategies, campaigns and processes R E L E N T L E S S L Y

14. Summary of lessons learned Recognize the balance between local site initiatives and national campaigns, and accommodate Sites can have other priorities Recognize and acknowledge good work when you see it

15. Acknowledgements The site staff making first contact with potential participants The trial participants, without whom this work would not be possible