1. Lymphatic System and Immunity
Anatomy & Physiology
Chapter 12

2. Chapter Assignments
Chapter 12 Text notes, pg Workbook , 249, 251

3. The Lymphatic System: Vessels, Nodes, and Organs
Text p WB

4. Lymphatic System Purpose: Return escaped fluids back to the blood
Filter fluid and remove foreign substances (Immune Response – Body Defense)
Consists of two semi-independent parts:
Lymphatic vessels
Lymphoid tissues and organs

5. Lymphatic Organs Tonsils Thymus Spleen Peyer’s patches Appendix
(in pharyngeal region)
Thymus
(in thorax; most active
during youth)
Spleen
(curves around left
side of stomach)
Peyer’s patches
(in intestine)
Appendix

6. Tonsils in your Mouth

7. The Thymus

8. The Spleen

9. Lymphatic System – Vessels and nodes
Lymph vessels
Lymph node
Ducts
Right lymphatic
Left thoracic
3 L interstitial fluid / day
Return leaked fluid
Filter/clean fluids

10. Lymphatic Vessels Transport Fluids From Intercellular Spaces Back to the Bloodstream

11. System and vessel relationship Flow of Lymph
Venous
system
Arterial
Lymphatic
Heart
Blood
capillaries
Loose connective
tissue around

12. Capillaries and interstitial fluid
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13. Lymphatic Capillaries

14. © 2015 Pearson Education, Inc.
Blind-end capillary
© 2015 Pearson Education, Inc.

15. Special structural features of lymphatic capillaries
Endothelial
cell
Flaplike
minivalve
Filaments
anchored to
connective
tissue
Special structural features of lymphatic capillaries

16. Lymph Drainage Thoracic duct Spleen Entrance of right
lymphatic duct into
right subclavian vein
Thoracic duct
Spleen
KEY:
Drained by the right lymphatic duct
Drained by the thoracic duct

17. Lymph Movement
Video

18. © 2015 Pearson Education, Inc.
Lymph Node
© 2015 Pearson Education, Inc.

19. Lymph Nodes Contain many lymphocytes and macrophages
Lymph nodes filter lymph before returning it to the blood
Harmful materials that are filtered:
Bacteria
Viruses
Cancer cells
Cell debris

20. Lymph Node

21. © 2015 Pearson Education, Inc.
Edema – when lymph is not taken up well Normal uptake = 3 liters lymph returned in 24 hr
© 2015 Pearson Education, Inc.

22. The Immune System: Body Defenses Non-Specific Response
Text p WB

23. TWO Body Defense Systems
Innate defense system
Non-specific
1st line
2nd line
Adaptive defense system
Specific
3rd line

24. Innate Defense System
1st line of defense
Skin / mucous membrane
Chemical secretions
Reflexes

25. Innate Defense System 2nd line of defense Phagocytic cells
Inflammatory response
Fever
Antimicrobial proteins
Natural killer cells

26. 1. Phagocytic Cells
Neutrophils are active during short term or acute infection

27. Phagocytic Cell – Immune Response

28. 2. Inflammatory Response Signs: Redness, heat, swelling, pain

29. 3. Fever Hypothalamus thermostat
reset higher by pyrogens (secreted by WBCs)
High temperatures
inhibit the release of iron and zinc from liver and spleen
(Bacteria need iron and zinc to survive)
Speed of repair processes increases

30. 4. Antimicrobial Proteins
Enhance innate defenses by:
Attacking microorganisms directly (COMPLEMENT PROTEINS)
Hindering reproduction of microorganisms (INTERFERON)
Complement proteins
30+ blood proteins that destroy microorganisms
Interferon
Proteins that inhibit viral replication

31. 5. Natural Killer (NK) Cells
Lyse and kill cancer cells, virus-infected cells
Release a chemical called perforin
Perforin causes cell membrane and nucleus to dissolve

32. In Review:

33. Text p. 410-420 Play Immunity Game – 30 min (at least)
The Immune System: Body Defenses Specific Response (Humoral, antibody-mediated)
Text p
Play Immunity Game – 30 min (at least)

34. Adaptive Defense System
3rd line of defense
Humoral
Antibodies
Macrophages
Lymphocytes
B cells
Cellular
T cells
Immunity—specific resistance to disease

35. Antibodies

36. Conflict: Immunity Game Your Challenge – Complete all levels!!

38. The Immune System: Body Defenses Specific Response (Humoral, antibody-mediated) (Cellular, cell-mediated)
Text p
WB , 249

39. Humoral Immune Response

40. Cell Mediated Immune Response

41. Humoral and Cell-Mediated Immune Response

42. The Immune System: Vaccination
WB 251

43. Active vs Passive Immunity
Active – your body makes the antibodies in response to pathogen Passive – your body receives antibodies from another source Which images represents Active and Passive Immunity?

44. Vaccination – Artificial Active Immunity
How do vaccines work?