1. Systemic treatment for colorectal cancer
Ian Ingledew

2. Who gets what? Site of disease Stage
Colon, rectum, anal cancer
Stage
Early disease (low risk – no chemo required)
Early disease (high risk factors)
Advanced/metastatic disease
Resectable liver metastases?

3. Drugs Fluorouracil (5FU) Calcium Folinate (not chemo) Capecitabine
Oxaliplatin
Irinotecan
Mitomycin
Cetuximab (KRAS mutation)?
Trifluridine/tipiracil (Lonsurf)

4. Common treatments OxMdG XELOX IrMdG +/- Cetuximab Chemoradiotherapy
Capecitabine
Infusional 5FU
Mitomycin + 5FU (anal cancer)

5. Side effects Myelosuppression Diarrhoea Nausea/vomiting
Capecitabine
Irinotecan
Nausea/vomiting
Sensory peripheral neuropathy (temperature sensitive)
Rash (cetuximab)

6. Cetuximab rash