1. The determinants of the interswitch toggle.
The determinants of the interswitch toggle. (A) The hydrogen bond network of the interswitch toggle signature in Arf6‐GTPγS. (B) The short interswitch is required for complete retraction of the interswitch. Comparison of the short interswitch of Arf6 to the long interswitch of Ran (Protein Data Bank entries 1A2K and 1K5D). Only the core of Arf6‐GTPγS is shown for clarity. (C) The N‐terminal hasp fastens the retracted conformation of the interswitch (red) in the GDP‐bound structures of human Arf1(Amor et al., 1994) and Arf6 (Menetrey et al., 2000), yeast Arl1(Amor et al., 2001), murine Arl3 (Hillig et al., 2000) and hamster Sar1 (Huang et al., 2001). The spatial volume occupied by the N‐terminus is similar in all structures regardless of its exact conformation. Only the core of Arf6‐GDP is shown for clarity.
Sebastiano Pasqualato et al. EMBO Rep. 2002;3:
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