1. From SubPAR to PAR, into the CryoEM, and More Macrolides
Cell Chemical Biology 
Volume 23, Issue 6, Pages (June 2016)
DOI: /j.chembiol
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2. Gibson et al. use an analog-sensitive strategy to control the poly(ADP-ribosyl) transferase reaction in cells. Chains of ADP-ribosyls are efficiently formed and amenable to different types of analysis and manipulation. (Image by Toni Lozano, via Wikimedia Commons.)
Cell Chemical Biology  , DOI: ( /j.chembiol )
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3. Resolution of structures solved by cryo-electron microscopy (cryoEM) has been steadily improving. Merk et al., and all of us, find ourselves at the beginning of a new chapter in the cryoEM era in which images of even smaller proteins and the small molecules they bind, are sharp and crisp, inviting us to take a closer look and then stay awhile.
Cell Chemical Biology  , DOI: ( /j.chembiol )
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4. Erythromycin and other macrolide antibiotics, in general, have complex chemical structures, and they have not been easy to synthesize de novo and derivatize through semi-synthetic strategies. Seiple et al. now present a remarkable way to make a variety of macrolide antibiotics and make them readily available for antibacterial activity validation.
Cell Chemical Biology  , DOI: ( /j.chembiol )
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