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DAPT Duration in PCI: The Art of Medicine When the Science Might Not Exist
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European and US Guidelines
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European and US Guidelines
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“Optimal” DAPT Duration and DES Revascularization A Less than “Optimal” Evidence Basis
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Long-Term DAPT: Bleeding Risk
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PRODIGY: 2-Year Death/MI/Stroke
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PRODIGY: 2-Year BARC 2, 3, or 5 Bleeding
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PRODIGY: Outcomes Relative to Stent Type and DAPT Duration
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PRODIGY: Outcomes Relative to Stent Type and DAPT Duration
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PRODIGY: Outcomes Relative to Stent Type and DAPT Duration
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REAL-LATE/ZEST-LATE: 2-Year End Points
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RCT Sample Size Calculations (6 mo vs 12 mo) Delta, Event-free Duration, Time to End Point Influence (N)
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DAPT Trial: Total Enrollment
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Pooled Xience EES Analysis Timing of First DAPT Interruption and ST Through 1 Year
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RESOLUTE Pooled DAPT Interruption Analysis Timing of First DAPT Interruption and ST Through 1 Year
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RESOLUTE Pooled DAPT Interruption Analysis Timing of First DAPT Interruption and ST Through 1 Year
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Global Leaders
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WOEST 1-Year Outcomes: ASA/Clopidogrel/Warfarin vs Clopidogrel/Warfarin
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DAPT Trial Randomization Rates
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Conclusions
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Conclusions (cont)
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Conclusions (cont)
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Conclusions (cont)
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双重抗血小板治疗的 合适使用时间及如何合理应用
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展望
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Spanish Perspective
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Recommendation for 12 Months of DAPT After DES Implantation
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Recommended Duration of DAPT After PCI
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Discontinuation of Antiplatelet Therapy as Predictor of Stent Thrombosis
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Pipeline: RCT on DAPT After Stenting
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EES vs PES: 1-Year Meta-Analysis (n = 6683)
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References
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References (cont)
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References (cont)
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Abbreviations
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Abbreviations (cont)
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Abbreviations (cont)
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Abbreviations (cont)
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Abbreviations (cont)
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