1. The Effect of Higher Protein Dosing in Critically ill Patients: A Multicentre Registry-based Randomized Trial
Purpose
To investigate the effects of higher protein dosing (≥2.2 g/kg/d) vs lower protein dosing (≤1.2 g/kg/d) on clinical outcomes in critically ill patients with nutrition ‘risk factors’.
Hypothesis
A higher delivery of protein/amino acids to nutritionally high-risk critically ill patients will be associated with improved survival and a quicker rate of recovery.
Inclusion Criteria
Adult patients ≥ 18 years old
Nutritionally ‘high-risk’ (have one or more of the following):
Low (≤25) or high BMI (≥35)
Moderate to severe malnutrition (as defined by local assessments).
Frailty (Clinical Frailty Scale ≥5, obtained from proxy)
Sarcopenia (SARC-F score ≥4, obtained from proxy)
From point of screening, a projected duration of mechanical ventilation >4 days
Requiring mechanical ventilation with actual or expected total duration of mechanical ventilation > 48 hours
Questions can be directed to the:
[ICU Dietitian or Site Investigator], [Name], at [Phone number and/or ]
For more information about the EFFORT Trial, visit us on CCN:
Clinicaltrials.gov NCT