1. HHM 5014 NUTRACEUTICAL FORMULATION TECHNOLOGY
UNIT 5: FORMULATION OF SOLID DOSAGE FORM (TABLETS & CAPSULE)
SUB-UNIT : 5.1 FORMULA
5.2 THE FUNCTION OF EACH INGREDIENTS
LUQMAN SYAMIMI AZALEA LIANA
SIR NOOR MUHAMMAD SYAHRIN YAHYA

2. INTRODUCTION
Pharmaceutical formulation is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. Tablets may be defined as the solid unit dosage form of medicament or medicaments with or without suitable excipients and prepared either by moulding or by compression Capsules are solid dosage form of medication in which the drug is enclosed in either a hard or soft soluble container or shell made of gelatin.

4. FORMULA Ibuprofen 200 mg 158 mg 32 mg 8 mg 2 mg
Microcrystalline cellulose
158 mg
Hydroxypropyl cellulose
32 mg
Crosscarmellose sodium
8 mg
Magnesium stearate
2 mg

5. used for treating pain, fever, and inflammation.
INGREDIENTS
FUNCTION
Ibuprofen
used for treating pain, fever, and inflammation.
reducing hormones that cause inflammation and pain in the body.
Microcrystalline cellulose
used as pharmaceutical excipients and disintegrating agents of tablets
Hydroxypropyl cellulose
used as a rate-controlling polymer for sustained-release dose forms
Crosscarmellose sodium
used to disintegrate tablet after oral administration 
Magnesium stearate
diluent for the manufacture of tablet, capsule, and powder dosage forms.

7. FORMULA Acyclovir HPMC K4M Sodium bicarbonate Succinic acid 200 mg

8. Hydroxypropyl methylcellulose
INGREDIENTS
FUNCTION
Acyclovir
used to treat infections caused by certain types of viruses
Hydroxypropyl methylcellulose
Protect valuable ingredients from stomach acid
Food additive
Sodium bicarbonate
Used to relieving indigestion
Used to prevent heartburn
Succinic acid
Help to increase the amount of iron in body
Improve appetite

9. FORMULATION OF SOFT GELATIN CAPSULES
Critical parameter: viscosity as measured by bloom strength
Low viscosity : thin weak films that take long time to dry
High viscosity: thick hard and often brittle films
Plasticizers(glycerol/gelatin )
Glycerol
Sorbitol
Propylene glycol
Water
water/part gelatin
Colours and opacifiers
Contents
Liquids (oils and polar liquids such as PEG)
Water and ethanol max 10%
Self emulsifying oils
Miroemulsions
Suspensions

10. FUNCTIONS OF INGREDIENTS OF SOFT GELATIN CAPSULES
Colour- The colour that used in shell has to be darker than colour of encapsulating material.
Opacifier- Usually Titanium dioxide, may be added to produce an opaque shell, when the fill formulation is a Suspension or to prevent photo degradation of light sensitive fill ingredients.
Plasticizer- Used to make the soft gel elastic and pliable.
Chelating agents- Iron is always present in raw gelatin and should not contain iron more than 15 ppm. It can also be used to prevent the reaction of iron with materials or colours.

11. CONCLUSION
1. Formulation is a mixture or a structure such as a capsule, a pill, tablet, or an emulsion, prepared according to a specific procedure (called a “formula”).
2. Formulations are a very important aspect of creating medicines, since they are essential to ensuring that the active part of the drug is delivered to the correct part of the body, in the right concentration, and at the right rate (not too fast and not too slowly).
3. Formulations for particular products that are safer, more effective, and more economical than any of their components used individually.