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Polymorphism in the Promoter Region of the Insulin-like Growth Factor I Gene Is Related to Carotid Intima-Media Thickness and Aortic Pulse Wave Velocity.

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Presentation on theme: "Polymorphism in the Promoter Region of the Insulin-like Growth Factor I Gene Is Related to Carotid Intima-Media Thickness and Aortic Pulse Wave Velocity."— Presentation transcript:

1 Polymorphism in the Promoter Region of the Insulin-like Growth Factor I Gene Is Related to Carotid Intima-Media Thickness and Aortic Pulse Wave Velocity in Subjects With Hypertension by A.F.C. Schut, J.A.M.J.L. Janssen, J. Deinum, J.M. Vergeer, A. Hofman, S.W.J. Lamberts, B.A. Oostra, H.A.P. Pols, J.C.M. Witteman, and C.M. van Duijn Stroke Volume 34(7): July 1, 2003 Copyright © American Heart Association, Inc. All rights reserved.

2 Figure 1. IMT by IGF-I genotype in normotensive subjects, all hypertensive subjects, and untreated hypertensive subjects. Figure 1. IMT by IGF-I genotype in normotensive subjects, all hypertensive subjects, and untreated hypertensive subjects. Analysis was adjusted for age, sex, BMI, total cholesterol, HDL cholesterol, diabetes mellitus, and smoking. *P<0.05, significantly different from homozygous carriers in all hypertensive subjects. **P<0.01, significantly different from homozygous carriers in untreated hypertensive subjects. A.F.C. Schut et al. Stroke. 2003;34: Copyright © American Heart Association, Inc. All rights reserved.

3 Figure 2. PWV by IGF-I genotype in normotensive subjects, all hypertensive subjects, and untreated hypertensive subjects. Figure 2. PWV by IGF-I genotype in normotensive subjects, all hypertensive subjects, and untreated hypertensive subjects. Analysis was adjusted for age, sex, BMI, total cholesterol, HDL cholesterol, diabetes mellitus, and smoking. *P<0.05, significantly different from homozygous carriers in all hypertensive subjects. **P<0.05, significantly different from homozygous carriers in untreated hypertensive subjects. A.F.C. Schut et al. Stroke. 2003;34: Copyright © American Heart Association, Inc. All rights reserved.


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