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Shigella-specific serum IgG and IgA endpoint titers in guinea pigs immunized intranasally with S. flexneri 2a InvaplexNAT or InvaplexAR. Shigella-specific.

Published byΙωάννα Λόντος Modified over 6 years ago

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Presentation on theme: "Shigella-specific serum IgG and IgA endpoint titers in guinea pigs immunized intranasally with S. flexneri 2a InvaplexNAT or InvaplexAR. Shigella-specific."— Presentation transcript:

1 Shigella-specific serum IgG and IgA endpoint titers in guinea pigs immunized intranasally with S. flexneri 2a InvaplexNAT or InvaplexAR. Shigella-specific serum IgG and IgA endpoint titers in guinea pigs immunized intranasally with S. flexneri 2a InvaplexNAT or InvaplexAR. Groups of guinea pigs (n = 6/group) were immunized intranasally on days 0, 14, and 28. Dose amounts of S. flexneri 2a InvaplexNAT and S. flexneri 2a InvaplexAR are indicated on the x axis. Guinea pigs were challenged on day 49 with S. flexneri 2a strain 2457T. Blood was collected on days 0, 28, 40, and 63 and analyzed by ELISA for anti-S. flexneri 2a LPS (top panels) or IpaB (middle panels) or IpaC (bottom panels) serum IgG (left panels) and IgA (right panels) endpoint titers. The mean endpoint titer + 1 standard error of the mean on day 40 is plotted, and significant differences (two-way analysis of variance; P < 0.05) between dose-matched groups are indicated with an asterisk. K. Ross Turbyfill et al. mSphere 2018;3:e ©2018 by American Society for Microbiology

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