Presentation is loading. Please wait.

Presentation is loading. Please wait.

The Biochemical Basis of Cobalamin Deficiency

Published byCameron Glenn Modified over 6 years ago

Similar presentations

Presentation on theme: "The Biochemical Basis of Cobalamin Deficiency"— Presentation transcript:

1 The Biochemical Basis of Cobalamin Deficiency
AYALEW TEFFERI, M.D., RAJIV K. PRUTHI, M.D.  Mayo Clinic Proceedings  Volume 69, Issue 2, Pages (February 1994) DOI: /S (12) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Fig. 1 Chemical structure of cobalamins. (Modified from Chanarin I. The Megaloblastic Anaemias. 2nd ed. Oxford: Blackwell, By permission.) Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Fig. 2 A, Cofactor activity of methylcobalamin (CH3-Cbl) in methionine synthesis. THF = tetrahydrofolate. B, Cofactor activity of adenosylcobalamin (Ado-Cbl) in succinyl-coenzyme A (CoA) synthesis. MeMaCoA = methylmalonyl-coenzyme A. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

4 Fig. 3 Enteric processing and absorption of cobalamin (Cbl). IF = intrinsic factor; R-binder = a cobalophilin with a rapid (compared with IF) electrophoretic mobility; TCii = transcobalamin II. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

5 Fig. 4 Chemical structure of folic acid.
Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

6 Fig. 5 Enteric processing and absorption of folates. Me = methyl; PGA1 and PGAn = pteroylglutamic acid (folic acid)—monoglutamated and polyglutamated forms; THF1 = monoglutamated form of tetrahydrofolate. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

7 Fig. 6 Intracellular interdependent cofactor activity of cobalamin (Cbl) and folate. CH3 = methyl group; THF1 and THFn = monoglutamated and polyglutamated forms of tetrahydrofolate. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1994 Mayo Foundation for Medical Education and Research Terms and Conditions

Download ppt "The Biochemical Basis of Cobalamin Deficiency"

Similar presentations

Megaloblastic anemias MA are a group of disorders characterized by defective nuclear maturation caused impaired DNA synthesis. This is usually due to vitamin.

Megaloblastic anemias MA are a group of disorders characterized by defective nuclear maturation caused impaired DNA synthesis. This is usually due to vitamin.
Use of Doppler Techniques (Continuous-Wave, Pulsed-Wave, and Color Flow Imaging) in the Noninvasive Hemodynamic Assessment of Congenital Heart Disease.

Use of Doppler Techniques (Continuous-Wave, Pulsed-Wave, and Color Flow Imaging) in the Noninvasive Hemodynamic Assessment of Congenital Heart Disease.
Malignant Hypertension as a Presenting Symptom of Takayasu Arteritis Talya Wolak, MD, Gabriel Szendro, MD, Luis Golcman, MD, Esther Paran, MD Mayo Clinic.

Malignant Hypertension as a Presenting Symptom of Takayasu Arteritis Talya Wolak, MD, Gabriel Szendro, MD, Luis Golcman, MD, Esther Paran, MD Mayo Clinic.
My Treatment Approach to Hairy Cell Leukemia Rahul R. Naik, MD, Alan Saven, MD Mayo Clinic Proceedings Volume 87, Issue 1, Pages 67-76 (January 2012) DOI:

My Treatment Approach to Hairy Cell Leukemia Rahul R. Naik, MD, Alan Saven, MD Mayo Clinic Proceedings Volume 87, Issue 1, Pages (January 2012) DOI:
Pleomorphic Adenoma in the Parotid Gland

Pleomorphic Adenoma in the Parotid Gland
Managing Cancer Pain: Basic Principles and Invasive Treatments

Managing Cancer Pain: Basic Principles and Invasive Treatments
Practical Algorithms in Anemia Diagnosis

Practical Algorithms in Anemia Diagnosis
Ductal Carcinoma in Situ of the Breast

Ductal Carcinoma in Situ of the Breast
55-Year-Old Man With Anemia and Hemorrhagic Ascites

55-Year-Old Man With Anemia and Hemorrhagic Ascites
Kayser-Fleischer Rings in a Patient With Basal Cell Carcinoma: Fortuitous Diagnosis of Presymptomatic Wilson's Disease  DAVID G. BRODLAND, M.D.  Mayo.

Kayser-Fleischer Rings in a Patient With Basal Cell Carcinoma: Fortuitous Diagnosis of Presymptomatic Wilson's Disease  DAVID G. BRODLAND, M.D.  Mayo.
Noninvasive Ventilation

Noninvasive Ventilation
Evaluation of Proteinuria

Evaluation of Proteinuria
How to Interpret and Pursue an Abnormal Prothrombin Time, Activated Partial Thromboplastin Time, and Bleeding Time in Adults  Arif H. Kamal, MD, Ayalew.

How to Interpret and Pursue an Abnormal Prothrombin Time, Activated Partial Thromboplastin Time, and Bleeding Time in Adults  Arif H. Kamal, MD, Ayalew.
De Novo Systemic Vasculitis in a Renal Transplant Recipient

De Novo Systemic Vasculitis in a Renal Transplant Recipient
Diagnostic Options for Assessment of Postmenopausal Bleeding

Diagnostic Options for Assessment of Postmenopausal Bleeding
Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy: Case Discussion and Review of the Literature  Paul Y. Kwo, M.D., William J. Tremaine, M.D.  Mayo.

Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy: Case Discussion and Review of the Literature  Paul Y. Kwo, M.D., William J. Tremaine, M.D.  Mayo.
William L. Lanier, MD  Mayo Clinic Proceedings 

William L. Lanier, MD  Mayo Clinic Proceedings 
Mark A. Nyman, M.D., Nina M. Schwenk, M.D., Marc D. Silverstein, M.D. 

Mark A. Nyman, M.D., Nina M. Schwenk, M.D., Marc D. Silverstein, M.D. 
Mucinous Neoplasm of the Appendix and Pseudomyxoma Peritonei

Mucinous Neoplasm of the Appendix and Pseudomyxoma Peritonei
Treatment of Alcohol Withdrawal in Hospitalized Patients

Treatment of Alcohol Withdrawal in Hospitalized Patients

Similar presentations

Ads by Google