1. Absolute Quantification of Myocardial Blood Flow
Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
Absolute Quantification of Myocardial Blood Flow
National Institute of Radiological Sciences
Hokkaido University of Graduate School of Medicine
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2. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
BACKGROUND
1-Increasing availability of positron emission tomography myocardial perfusion imaging
2- Absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings
3-Evidences of clinical role of MBF have been developed
4- MBF quantification also have been applied for other imaging including SPECT, CTA, and CMR
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3. METHODS Study type:(Select all that apply)
Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
METHODS
Study type:(Select all that apply)
Prospective/retrospective/randomized/double blind/placebo controlled/observational/case control/cohort.
Study subjects: (one sentence summarizing included and/or excluded subjects)
Study endpoints:
Primary end point(s):
Secondary end point(s):
Study variables
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4. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
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5. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
If figure, insert legend Net extraction by the myocardium as a function of myocardial blood flow with PET flow tracers and other contrast agents.
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6. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
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7. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
Insert a key table or a key figure If figure, insert legend Delete slide if second results slide not necessary
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8. If figure, insert legend
Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
If figure, insert legend
Time-intensity curves of the left ventricular cavity and myocardium.
Short-axis MR images at the basal level with the regions of interest (ROIs) set to create the time intensity curves for the left ventricular cavity and whole myocardium.
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9. RESULTS Modality Author Pt No. Diag standard Parameter Se (%) Sp (%)
Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
RESULTS
Modality
Author
Pt No.
Diag standard
Parameter
Se (%)
Sp (%)
15O-H2O
PET
Danad et al.
330
90% stenosis FFR<0.8
MFR=2.5 86 72
FFRCT
Min
285
FFR<0.8
&CTA 73 90
CT perfusion
Kurata 11
ICA stenosis>70%
Hyperemic MBF=1.74 88 68
CMR perfusion
Biglands 50
Hyperemic MBF=1.60
89.5 80
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10. Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology
CONCLUSIONS
1-Quantitative MBF measurements provide additional diagnostic value over conventional visual imaging
2- Reduced MFR associated with increasing cardiovascular events
3- Dynamic SPECT, CTA, and CMR have great possibilities to evaluate MBF
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