1. Latest Advances in HCM

3. Program Goals

4. Disease Burden

5. Complications and Pathways of Disease Progression

6. Diagnosis Physical Exam

7. Diagnosis Family History

8. Diagnosis ECG

9. Diagnosis Echocardiogram

10. Diagnosis Genetic Testing

11. Diagnosis Challenges

12. HCM Phenotypes Asymmetric Septal HCM

13. HCM Phenotypes Apical HCM

14. Diagnosis CMR Imaging

15. Symptoms

16. Obstructive HCM

17. Obstructive vs Nonobstructive HCM Assessment

18. Symptomatic Nonobstructive HCM ACCF/AHA Treatment Algorithm

19. Symptomatic Obstructive HCM ACCF/AHA Treatment Algorithm

20. Current Pharmacologic Therapies Verapamil

21. Current Pharmacologic Therapies Disopyramide

22. Current Pharmacologic Therapies Disopyramide (cont)

23. Current Pharmacologic Therapies β Blocker

24. Invasive Therapies ACCF/AHA Recommendations

25. Investigational Therapies

26. Ranolazine RHYME

27. MYK-461 Phase 1 Studies in Healthy Volunteers and Patients With HCM

28. Eleclazine LIBERTY-HCM

29. MitraClip™ Percutaneous Mitral Valve Plication

30. Summary

31. Abbreviations

32. Abbreviations (cont)

33. Abbreviations (cont)