1. Dengue
Eva Archer
BIO 402

2. What is Dengue?

3. Transmission http://en.citizendium.org/wiki/Dengue_Virus

4. Symptoms
Symptoms start 4-7 days after bite and last 3-10 days. To transmit to an uninfected mosquito, the mosquito must feed on a person during a five-day period when there are high amounts of virus in the blood. The virus must then incubate for 8-12 days in the mosquito before it can be transmitted to another human (mosquito is infected for life).
high fever, severe headache, severe pain behind the eyes, joint pain, muscle and bone pain, rash, mild bleeding (e.g., nose or gums bleed, easy bruising), low white cell count
Dengue Hemorrhagic Fever: after fever begins to decline (2-7 days), capillaries become permeable, allowing fluid to escape into peritoneum and pleural cavity – this can lead to failure of the circulatory system and shock (possibly death) without treatment.

5. 2.5 billion people (40%) in areas with risk of transmission
million infections yearly
500,000 cases of DHF
22,000 deaths

7. Viral Lifecycle
Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

8. Immunopathogenesis of Dengue Virus Infection
Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

9. Genome Organization
Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

11. Secondary infections and antibody-dependent enhancement