1. CPIC Update

2. CPIC: Clinical Pharmacogenetics Implementation Consortium
>130 Members
Clinicians and scientists
62 institutions
14 countries
12 Observers (NIH and FDA)
CPIC Informatics
17 members from 11 organizations
89 in 2013
42 institutions

3. Published CPIC Guidelines
2011
TPMT – thiopurines
Updated March 2013
CYP2C19 – clopidogrel
Updated Sept 2013
CYP2C9, VKORC1 – warfarin
postponed until after key studies published
2012
CYP2D6 – codeine
Updated Feb 2014
HLA-B – abacavir
Updated March 2014
SLCO1B1 – simvastatin
Updated July 2014
2013
HLA-B – allopurinol
Update progress
CYP2D6, CYP2C19 - TCAs
HLA-B - carbamazepine
DPYD - 5FU / capecitabine
2014
IL28B-PEG interferon α
CFTR-Ivacaftor
G6PD/Rasburicase
CYP2C9 and HLA-B/Phenytoin

4. CPIC Guidelines Status
Guidelines Underway
Guideline Updates
HLA-B/allopurinol: in progress
CYP2D6/SSRIs
Andrea Gaedigk
CYP3A5/tacrolimus
Iain MacPhee
UGT1A1/atazanavir
David Haas
CYP2C19/voriconazole
Finalizing senior author
CYP2D6/ondansetron
Guidelines Recently Published
CYP2C9 and HLA-B/Phenytoin
Tom Callaghan

5. CPIC guideline genes (n=13) and drugs, September 2014
TPMT
MP, TG, azathioprine
CYP2D6
Codeine, tramadol, hydrocodone, oxycodone, TCAs
CYP2C19
TCAs, clopidogrel, voriconazole
VKORC1
warfarin
CYP2C9
Warfarin, phenytoin
HLA-B
Allopurinol, CBZ, abacavir, phenytoin
CFTR
ivacaftor
DPYD
5FU, capecitabine, tegafur
G6PD
rasburicase
SLCO1B1
simvastatin
IFNL3 (IL28B)
interferon
CYP3A5
Tacrolimus
UGT1A1
atazanavir

6. CPIC guideline citations
2011
2012
2013
Black solid line indicates the average citation rates (total citations/total publications) for all publications in fields of Clinical Medicine and Pharmacology & Toxicology for same time period (2014 Journal Citation Reports® Science Edition (Thomson Reuters, 2014))

8. Guidelines.gov

9. ASHP and ASCPT are endorsing CPIC guidelines

10. Purpose: To describe the development process of the CPIC guidelines
To compare our process to the Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines

11. Caudle et al, Current Drug Metab 2014

14. CPIC’s future